Table 4

Canonical pathways altered in septic lungs treated with MSCs

PathwaysCombined scoreDatabase
Induction of apoptosis via DR3 and DR4/5 death receptors9.14BioCarta
Salmonella infection8.42KEGG
Apoptosis modulation by HSP707.29Reactome
FAS pathway and stress induction of HSP regulation6.64Reactome
Glycosphingolipid biosynthesis6.36KEGG
Wnt signalling pathway netpath6.26Reactome
Adipocytokine signalling pathway6.25KEGG
BDNF signalling pathway6.14Reactome
FAS signalling pathway5.99Panther
Neurotrophin signalling pathway5.66KEGG
ER-associated degradation pathway5.40BioCarta
Signal transduction of S1P receptor5.06Reactome
FAS signalling pathway (CD95)5.03BioCarta
AMPK signalling pathway5.03KEGG
Insulin signalling4.72Reactome
Fc gamma R-mediated phagocytosis4.08KEGG
mRNA surveillance pathway4.02KEGG
Nicotinic acetylcholine receptor signalling pathway3.90Panther
Cytoskeletal regulation by Rho GTPase2.98Panther
Nerve growth factor pathway2.70BioCarta
Huntington disease2.42Panther
CXCR4 signalling pathway2.39BioCarta
Apoptotic signalling in response to DNA damage1.94BioCarta
EGF signalling pathway1.86BioCarta
JAK/STAT signalling pathway1.75Panther
5HT3 type receptor-mediated signalling pathway1.32Panther
Muscarinic acetylcholine receptor 1 and 3 signalling pathway1.21Panther
5HT2 type receptor-mediated signalling pathway1.13Panther
5HT4 type receptor-mediated signalling pathway1.06Panther
p53 pathway0.51KEGG
Inflammation mediated by chemokine and cytokine signalling0.03Panther
Parkinson disease−0.40Panther
Epinephrine and norepinephrine biosynthesis−0.45KEGG
Alzheimer disease-amyloid secretase pathway−0.62Panther

  • EGF, epidermal growth factor ; HSP70, heat shock protein 70; MSC, mesenchymal stromal cell.