Multivariable Cox regression analyses models demonstrating mortality prediction determined by change in various visual CT variables (measured with 5-point ordinal scores) in the combined idiopathic pulmonary fibrosis cohorts (n=211)
| Categorical change in visual CT variables | HR, 95% CI, P value, Concordance Index |
| Total ILD extent | 1.68, 1.33 to 2.12, 5.9×10–5, 0.70 |
| Ground-glass opacity extent | 1.64, 1.28 to 2.09, 0.0004, 0.68 |
| Reticular pattern extent | 1.61, 1.26 to 2.05, 0.0007, 0.69 |
| Honeycombing extent | 1.90, 1.44 to 2.51, 2.7×10–5, 0.69 |
| Traction bronchiectasis severity | 2.14, 1.59 to 2.88, 2.5×10–6, 0.70 |
P values shown are adjusted for multiple comparisons.
Each visual CT variable was analysed in a separate model adjusted for patient age, gender, baseline disease severity using the diffusion capacity for carbon monoxide and antifibrotic use (never/ever).
ILD, interstitial lung disease.