Table 1

Baseline characteristics of the 22 patients

All (n=22)
Sex (men), n (%)12 (54.5)
Age63 (60; 66)
BMI, kg/m2 25.1 (6.3)
Smoking history, pack years40 (22)
LTOT, n (%)5 (22.7)
Lung function
 FEV1, % pred32 (27; 47)
 FVC, % pred79 (18)
 FEV1/FVC, %37.7 (11.1)
 TLC, % pred112 (22)
 RV, % pred178 (147; 205)
 VR/TLC, %58.2 (7.5)
 DLCO, % pred46 (20)
Arterial blood gases (at rest)
 PaO2, kPa9.5 (1.3)
 PaCO2, kPa6.0 (1.1)
 pH7.42 (0.03)
 HCO3 -, mmol/L27.5 (26.8; 29.4)
 SaO2, %94.3 (2.7)
Functional capacity and health status
 6MWT (m)406 (101)
mMRC score
 mMRC 2, n (%)9 (40.9)
 mMRC 3, n (%)12 (54.5)
 mMRC 4, n (%)1 (4.5)
HAD score
 Anxiety9 (5)
 Depression7 (4)
SGRQ (% maximum)
 Symptoms51 (43; 62)
 Activities72 (17)
 Impacts38 (15)
 Total score50 (14)
  • Mean (SD) or Median (25th;75th).

  • Arterial blood gases were collected on room air for patients who were normoxic at rest and under oxygen for patients with LTOT.

  • BMI, body mass index; DLCO, carbon monoxide transfer factor; F, female; FEV1, forced expiratory volume in one second; FVC, forced vital capacity; HAD, Hospital Anxiety Depression Scale; LTOT, long-term oxygen therapy; M, male; mMRC, modified Medical Research Council scale; 6MWT, Six Min Walk Test; PaCO2, arterial partial pressure of carbon dioxide; PaO2, arterial partial pressure of oxygen; RV, residual volume; SaO2, arterial oxygen saturation; SGRQ, St George’s Respiratory Questionnaire; TLC, total lung capacity.