Mortality outcome within subgroups of annualised FVC change for various visual CT variables
| FVC decline range | Categorical change in visual CT variables | Visual CT variables (HR, 95% CI, P value, Concordance Index) | FVC decline (HR, 95% CI, P value) |
| FVC 5.0%–9.9% decline | Total ILD extent | 3.09, 1.39 to 6.88, 0.03, 0.69 | 1.85, 0.04 to 78.77, 0.74 |
| Ground-glass opacity extent | 2.36, 1.04 to 5.35, 0.20, 0.66 | 0.72, 0.02 to 29.67, 0.86 | |
| Reticular pattern extent | 3.06, 1.34 to 7.01, 0.04, 0.69 | 1.52, 0.04 to 54.22, 0.82 | |
| Honeycombing extent | 3.79, 1.54 to 9.36, 0.02, 0.71 | 0.81, 0.02 to 32.13, 0.91 | |
| Traction bronchiectasis severity | 5.20, 2.19 to 12.32, 0.0009, 0.71 | 1.33, 0.03 to 65.14, 0.89 | |
| FVC ≥10% decline | Total ILD extent | 1.45, 1.06 to 1.99, 0.10, 0.57 | 0.97, 0.44 to 2.15, 0.94 |
| Ground-glass opacity extent | 1.43, 1.04 to 1.96, 0.13, 0.57 | 0.89, 0.42 to 1.92, 0.78 | |
| Reticular pattern extent | 1.31, 0.93 to 1.84, 0.58, 0.56 | 0.98, 0.43 to 2.22, 0.96 | |
| Honeycombing extent | 1.39, 0.99 to 1.95, 0.28, 0.57 | 0.92, 0.42 to 2.03, 0.84 | |
| Traction bronchiectasis severity | 1.63, 1.12 to 2.36, 0.049, 0.59 | 0.97, 0.445 to 2.10, 0.94 |
P values shown are adjusted for multiple comparisons.
The visual CT variables (measured with 5-point ordinal scores) were examined in separate multivariable Cox regression models adjusted for patient age, gender, baseline disease severity (using diffusion capacity for carbon monoxide) and antifibrotic use (never/ever). Analyses were performed in patients with an annualised FVC decline of 5.0%–9.9% (n=53) and ≥10% (n=107).
FVC, forced vital capacity; ILD, interstitial lung disease.