Diagnostic accuracy of the eight-protein biosignature in diagnosing TB
| Model | Group | Clinical diagnosis (n) | Classified as non-TB (n) | Classified as TB (n) | Cut-off value | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | Accuracy (95% CI) |
| Training (n=276) | Non-TB | 189 | 189 | 0 | 0.4 | 100% (96% to 100%) | 100% (98% to 100%) | 100% (98% to 100%) | 100% (96% to 100%) | 100% (99% to 100%) |
| TB | 87 | 0 | 87 | |||||||
| Test (n=92) | Non-TB | 63 | 52 | 11 | 0.4 | 76% (56% to 90%) | 83% (71% to 91%) | 88% (77% to 95%) | 67% (48% to 82%) | 80% (71% to 88%) |
| TB | 29 | 7 | 22 | |||||||
| Prediction (n=102) | Non-TB | 70 | 59 | 11 | 0.4 | 75% (57% to 89%) | 84% (74% to 92%) | 88% (78% to 95%) | 69% (51% to 83%) | 81% (72% to 88%) |
| TB | 32 | 8 | 24 |
NPV, negative predictive value; PPV, positive predictive value.