Expression of zinc transporters in the lung
| Transporter | Control | Zn | LPS (control) | LPS (Zn) |
| Zip4 | 11.9 (5.5 to 16.9) | 16.2 (9.2 to 2.17) | 18.4 (17.8 to 23.0) | 25.3 (21.6 to 31.7) |
| Zip6 | 0.33 (0.28 to 0.46) | 0.46 (0.37 to 0.52) | 0.48 (0.25 to 0.52) | 0.37 (0.28 to 0.47) |
| Zip8 | 4.9 (3.49 to 5.32) | 7.06* (6.13 to 7.82) | 5.99 (5.31 to 6.83) | 7.59 (5.88 to 8.50) |
| Zip10 | 1.65 (0.98 to 3.09) | 1.7 (1.42 to 2.29) | 1.79 (1.56 to 1.96) | 1.54 (1.50 to 3.66) |
| Zip14 | 0,76 (0.34 to 0.99) | 0.90 (0.61 to 1.10) | 3.35 (1.34 to 4.80) | 4.43 (4.34 to 6.46) |
| ZnT1 | 9.23 (8.73 to 11.5) | 18.62* (14.84 to 21.63) | 13.34 (12.16 to 17.70) | 15.26 (11.33 to 15.72) |
| ZnT5 | 2.33 (1.60 to 7.90) | 5.37 (2.67 to 7.96) | 3.33 (1.23 to 6.64) | 2.54 (1.49 to 3.44) |
Mice were treated as described in materials and methods. Median and IQR (25th and 75th percentile) are shown. Statistical significance of results was assessed by Mann-Whitney U test (*p <0.05). Effects of zinc alone and on LPS-induced expression were investigated for zinc transporters that were previously found most relevant in regard to lung injury.7 14 43
LPS, lipopolysaccharides; Zn, zinc.