Associations of longitudinal patterns of SHS, pets, and dampness or mould exposure with per cent difference in annual growth of FEV1 and FVC from ages 12 to 16
| % difference in FEV1 growth/year (95% CI) | % difference in FVC growth/year (95% CI) | |||
| Crudeα (n=552) | Adjustedβ (n=525) | Crudeα (n=552) | Adjustedβ (n=525) | |
| SHS | ||||
| Persistently low vs very low | 0.16 (−0.14 to 0.47) | 0.30 (−0.01 to 0.62) | 0.20 (−0.11 to 0.50) | 0.31 (0.00 to 0.64) |
| Early life vs very low | 0.15 (−0.13 to 0.44) | 0.31 (0.01 to 0.61) | 0.06 (−0.22 to 0.35) | 0.32 (0.03 to 0.62) |
| Childhood vs very low | −0.48 (−0.76 to −0.19) | −0.34 (−0.64 to −0.04) | −0.28 (−0.56 to −0.00) | −0.04 (−0.33 to 0.26) |
| Pets | ||||
| Early life vs very low | −0.03 (−0.28 to 0.21) | 0.02 (−0.24 to 0.27) | −0.34 (−0.58 to −0.10) | −0.28 (−0.53 to −0.03) |
| Mid-childhood vs very low | −0.23 (−0.52 to 0.07) | −0.09 (−0.40 to 0.21) | −0.16 (−0.45 to 0.13) | −0.04 (−0.34 to 0.26) |
| Late childhood vs very low | 0.18 (−0.07 to 0.43) | 0.41 (0.14 to 0.67) | −0.46 (−0.70 to −0.21) | −0.14 (−0.39 to 0.12) |
| Persistently high vs very low | −0.32 (−0.51 to −0.14) | −0.26 (−0.46 to −0.06) | −0.43 (−0.61 to −0.25) | −0.33 (−0.53 to −0.14) |
| Dampness or mould | ||||
| Early life vs very low | −0.74 (−1.01 to −0.46) | −0.77 (−1.05 to −0.49) | −0.53 (−0.81 to −0.26) | −0.56 (−0.83 to −0.28) |
| Moderate late childhood vs very low | 0.10 (−0.14 to 0.35) | 0.05 (−0.19 to 0.30) | 0.05 (−0.19 to 0.30) | −0.02 (−0.26 to 0.23) |
| Mid-childhood vs very low | 0.10 (−0.32 to 0.51) | 0.04 (−0.37 to 0.46) | −0.18 (−0.59 to 0.23) | −0.23 (−0.63 to 0.18) |
α Adjusted for sex, log transformations of differences in height, weight and age between the 12-year and 16-year lung function measurements. β Adjusted for sex, log transformations of differences in height, weight and age between the 12-year and 16-year lung function measurements, parental education, maternal and paternal allergy, breast feeding at 12 weeks, maternal smoking during pregnancy, indoor SHS at 1 year (except in models with SHS exposure), use of gas for cooking at 3 months, annual average NO2 concentration at the birth address, birth weight, dampness or mould in the child’s home at 1 year (except in models with dampness or mould exposure), pets in the home at 1 year (except in models with pet exposure), respiratory infections in the past 3 weeks before medical examination.
SHS, secondhand smoke.