Parameter estimates (95% CIs) and likelihood ratio test (LRT) p values for the interaction effect of diagnosis by NBS and deprivation on weight-for-age SD-core trajectories and %predicted FEV1 after adjustment for sex, genotype, year of birth, ethnicity, deprivation, diagnosis by NBS, diagnosis by MI and pancreatic insufficiency. Also, the estimated associations (95% CIs) of SECs with outcomes in the clinically diagnosed population and the population diagnosed by NBS based on the estimated interaction effects. All numbers were rounded to two digits
| Weight | %FEV1 | |
| Main effects | ||
| NBS: IMD interaction effect estimate | 0.01 (−0.06, 0.08) | 0.05 (−1.14, 1.25) |
| IMD effect in clinically diagnosed population | −0.08 (−0.13, −0.03) | −1.44 (−2.14, −0.74) |
| IMD effect in population diagnosed by NBS | −0.07 (−0.12, −0.03) | −1.39 (−2.36, −0.41) |
| Interaction effects with age | ||
| NBS:age: IMD interaction effect estimate | 0.01 (−0.00, 0.02) | NA |
| IMD: age interaction effect in clinically diagnosed population | 0.00 (−0.00, 0.01) | NA |
| IMD: age interaction effect in population diagnosed by NBS | 0.01 (0.01, 0.02) | NA |
| LRT p value* | 0.17 | 0.89 |
*Compared with model with no NBS: IMD interaction effects.
cPA, chronic Pseudomonas aeruginosa; FEV1, forced expiratory volume in one second; IMD, Index of Multiple Deprivation; NBS, newborn bloodspot screening.