Table 1

Models for categorical disease progression, death, first all-cause hospitalisation and adjudicated respiratory hospitalisation

Outcome	Stepwise selected baseline predictors	HR	95% CI for HR	C-index	95% CI for C-index
Categorical disease progression	Baseline FVC (required)*	0.98	(0.96 to 1.00)	0.69	(0.64 to 0.73)
	ΔFVC, weeks 0–14*†	0.51	(0.46 to 0.57)
	Baseline FEV₁/FVC	1.03	(1.01 to 1.06)
	Baseline HRCT score	1.02	(0.01 to 1.03)
Death	Baseline FVC (required)*	0.97	(0.90 to 1.04)	0.64	(0.54 to 0.73)
	ΔFVC, weeks 0–14*†	0.76	(0.61 to 0.95)
	Baseline DLCO% predicted	0.95	(0.91 to 1.00)
	Baseline FEV₁/FVC	1.11	(1.04 to 1.18)
	Log (LOXL2)	2.96	(1.26 to 6.94)
	Log (IPF duration of diagnosis)	0.63	(0.42 to 0.95)
All-cause hospitalisation	Baseline FVC (required)*	1.01	(0.98 to 1.04)	0.76	(0.73 to 0.79)
	BMI	0.95	(0.91 to 0.99)
	Baseline DLCO% predicted	0.97	(0.95 to 0.99)
	Baseline FEV₁/FVC	1.03	(1.00 to 1.07)
	Baseline SGRQ score	1.02	(1.01 to 1.02)
	Baseline HRCT score	1.02	(1.01 to 1.04)
Adjudicated respiratory hospitalisation	Baseline FVC (required)*	1.00	(0.96 to 1.03)	0.72	(0.67 to 0.77)
	ΔFVC, weeks 0–14*†	0.82	(0.73 to 0.93)
	Baseline DLCO% predicted	0.95	(0.93 to 0.97)
	Baseline FEV₁/FVC	1.06	(1.02 to 1.09)
	Baseline SGRQ score	1.02	(1.01 to 1.03)

*Variable analysed in 100 mL increments.
†ΔFVC analysed in 100 mL increments, with HR of <1. In the Abstract and Results sections, ΔFVC was analysed in 100 mL decrements, with HR >1.
BMI, body mass index; DLCO, diffusion capacity for carbon monoxide; FEV₁, forced expiratory volume in one second/forced expiratory volume; ΔFVC, change in forced vital capacity; FVC, forced vital capacity; HRCT, high-resolution CT; IPF, idiopathic pulmonary fibrosis; LOXL2, lysyl oxidase-like 2; SGRQ, St George’s Respiratory Questionnaire.