ARG | Classification | BEAT | EXC EED | EvA (Pt)* | EvA (ctrl)* |
No. samples | 165 | 29 | 8 | 7 | |
sulA/folP-01 | Sulfonamides | 93.5 | 100 | 75 | 71 |
sulA/folP-03 | Sulfonamides | 98.5 | 100 | 88 | 100 |
tetM-01 | Tetracyclines | 82.5 | 97 | 88 | 93 |
cfxA | β-lactams | 84.5 | 95 | 88 | + |
tetM-02 | Tetracyclines | 91.5 | 93 | 75 | 93 |
fabK | other | 80 | 90 | 100 | 86 |
matA/mel | MLSB | 85.5 | 90 | 75 | 100 |
mefA | MLSB | 69 | 90 | 88 | 100 |
pmrA | Multidrug | 88 | 83 | 88 | 100 |
tetQ | Tetracyclines | 75.5 | 79 | 88 | 100 |
IS613 | MGEs/Transposase | 59 | 76 | + | + |
tet(32) | Tetracyclines | 51 | 69 | + | + |
tetW-01 | Tetracyclines | 60 | 63 | + | + |
mtrD-02 | Multidrug | 67 | 62 | + | + |
ceoA | Multidrug | 30 | 59 | + | + |
tetPB-02 | Tetracyclines | 66 | 59 | + | – |
vanC-03 | Vancomycin | 49.5 | 59 | + | – |
fox5 | β-lactams | 55 | 56 | + | – |
ermB | MLSB | 70 | 55 | + | + |
pncA | Pyrazinamide | 33.5 | 55 | – | – |
tetO-01 | Tetracyclines | 53.5 | 55 | + | + |
catB8 | FCA | 41.5 | 52 | + | + |
mphA-01 | MLSB | 50.5 | 52 | – | + |
intI1 | Integrase | 81 | 45 | + | + |
pbp2x | β-lactams | 52.5 | 21 | + | + |
A lookup table (low-high, green-red) has been applied to facilitate comparisons. ARGs present in >50% of samples have been ordered according to their prevalence in the EXCEED (healthy) group. Boxes highlight differences between BEAT and EXCEED studies.
*Due to the low number of samples in these groups frequencies below 70% were reported as + or – to denote presence or absence of signals. The colours reflect a heatmap of the relative frequency values.
ARG, antimicrobial resistance gene; FCA, fluroquinolone, quinolone, florfenicol, chloramphenicol, and amphenicol resistance genes; MGE, mobile genetic elements; MLSB, Macrolide-Lincosamide-Streptogramin B resistance.