Table 3

Frequency of positive signals for highly prevalent ARGs for all three study groups

ARGClassificationBEATEXC
EED
EvA
(Pt)*
EvA
(ctrl)*
No. samples1652987
sulA/folP-01 Sulfonamides93.51007571
sulA/folP-03 Sulfonamides98.510088 100
tetM-01 Tetracyclines82.5978893
cfxA β-lactams84.5 95 88 +
tetM-02 Tetracyclines91.59375 93
fabK other809010086
matA/mel MLSB85.59075100
mefA MLSB699088100
pmrA Multidrug888388100
tetQ Tetracyclines75.57988100
IS613 MGEs/Transposase5976++
tet(32)Tetracyclines5169++
tetW-01 Tetracyclines60 63 ++
mtrD-02 Multidrug6762++
ceoA Multidrug3059++
tetPB-02 Tetracyclines6659+
vanC-03 Vancomycin49.559+
fox5 β-lactams55 56 +
ermB MLSB7055++
pncA Pyrazinamide33.555
tetO-01 Tetracyclines53.555++
catB8 FCA41.552++
mphA-01 MLSB50.552+
intI1 Integrase8145++
pbp2x β-lactams52.521++
  • A lookup table (low-high, green-red) has been applied to facilitate comparisons. ARGs present in >50% of samples have been ordered according to their prevalence in the EXCEED (healthy) group. Boxes highlight differences between BEAT and EXCEED studies.

  • *Due to the low number of samples in these groups frequencies below 70% were reported as + or – to denote presence or absence of signals. The colours reflect a heatmap of the relative frequency values.

  • ARG, antimicrobial resistance gene; FCA, fluroquinolone, quinolone, florfenicol, chloramphenicol, and amphenicol resistance genes; MGE, mobile genetic elements; MLSB, Macrolide-Lincosamide-Streptogramin B resistance.