Table 5

Multivariable associations between doctor-diagnosed childhood pneumonia-pleurisy and static lung volumes in middle age

Episodes of pneumonia and/or pleurisy†Complete case (n)Static lung volumes at age 45‡§¶
TLCFRCRV
(z-score (SD, 95% CI))P value(z-score (SD, 95% CI))P value(z-score (SD, 95% CI))P value
At age 45
 0900RefRefRef
 ≥1197−0.26 (−0.4 to 0.1)***<0.001−0.21 (−0.3 to 0.1)**0.001−0.18 (−0.3 to 0.05)**0.008
 1–2178−0.24 (−0.4 to 0.1)***<0.001−0.21 (−0.3 to 0.1)**0.002−0.21 (−0.3 to 0.1)**0.004
 >219−0.37 (−0.7 to 0.02) *0.040−0.15 (−0.5 to +0.2)0.424+0.05 (−0.3 to +0.4)0.786
  • *P<0.05, **p<0.01, ***p<0.001.

  • †≥1 and >2 episodes refer to childhood pneumonia/pleurisy-ever and recurrent pneumonia/pleurisy in the main text, respectively.

  • ‡Multivariable adjustments include sampling weights, maternal/paternal smoking, socioeconomic status (paternal occupation, rurality of primary school) and history of breast/bottle feeding.

  • §RV/TLC results: childhood pneumonia/pleurisy-ever, z-score=−0.03 (−0.1 to +0.1), p=0.52; recurrent episodes +0.31 (0.03 to 0.59), p=0.028.

  • ¶¶If a statistical interaction is present, stratified results have been presented in the main text and correspond to online supplementary table E5 (by current childhood asthma), online supplementary table E6 (by participant sex) and online supplementary table E7 (by never/ever smoking).

  • FRC, functional residual capacity; Ref, reference; RV, residual volume; TLC, total lung capacity.