Table 4

Parameter estimates (95% CIs) and likelihood ratio test (LRT) p values for the interaction effect of diagnosis by NBS and deprivation on weight-for-age SD-core trajectories and %predicted FEV1 after adjustment for sex, genotype, year of birth, ethnicity, deprivation, diagnosis by NBS, diagnosis by MI and pancreatic insufficiency. Also, the estimated associations (95% CIs) of SECs with outcomes in the clinically diagnosed population and the population diagnosed by NBS based on the estimated interaction effects. All numbers were rounded to two digits

Main effects
NBS: IMD interaction effect estimate0.01 (−0.06, 0.08)0.05 (−1.14, 1.25)
IMD effect in clinically diagnosed population−0.08 (−0.13, −0.03)−1.44 (−2.14, −0.74)
IMD effect in population diagnosed by NBS−0.07 (−0.12, −0.03)−1.39 (−2.36, −0.41)
Interaction effects with age
NBS:age: IMD interaction effect estimate0.01 (−0.00, 0.02)NA
IMD: age interaction effect in clinically diagnosed population0.00 (−0.00, 0.01)NA
IMD: age interaction effect in population diagnosed by NBS0.01 (0.01, 0.02)NA
LRT p value*0.170.89
  • *Compared with model with no NBS: IMD interaction effects.

  • cPA, chronic Pseudomonas aeruginosa; FEV1, forced expiratory volume in one second; IMD, Index of Multiple Deprivation; NBS, newborn bloodspot screening.