Table 2

Parameter estimates (95% CIs) and likelihood ratio test (LRT) p values for the effect of diagnosis by NBS on weight-for-age SD-score trajectories, BM-for-age SD-score trajectories, %predicted FEV1 and cPA after adjustment for sex, genotype, year of birth, ethnicity, diagnosis by MI and pancreatic insufficiency. All numbers were rounded to two digits

WeightBMI%FEV1 cPA
Model with NBS main effect only
NBS effect estimate0.11 (0.03, 0.19)0.02 (−0.05, 0.09)1.56 (0.1, 3.02)1.31 (1.07, 1.62)
LRT p value<0.010.540.04<0.01
Model with NBS main effect and interaction with age
NBS effect estimate0.16 (0.07, 0.26)0.05 (−0.05, 0.14)0.87 (−0.88, 2.62)NA
NBS:age interaction effect estimate−0.02 (−0.03, −0.00)−0.01 (−0.02, 0.01)0.24 (−0.1, 0.58)NA
LRT p value*0.020.420.16NA
  • *Compared with model with NBS main effect only.

  • BMI, body mass index; cPA, chronic Pseudomonas aeruginosa; FEV1, forced expiratory volume in one second; NBS, newborn bloodspot screening.