Multivariate Cox regression analysis of survival in patients with advanced COPD
| HR | SE | CI | p-value | ||
|---|---|---|---|---|---|
| Age at first CRA (years) | 1.05 | 0.02 | 1.02 – 1.08 | <0.001 | |
| FEV1 (L) | 0.54 | 0.24 | 0.23 – 1.28 | 0.16 | |
| MRC dyspnoea scale grade | 0.94 | 0.24 | 0.8 – 1.54 | 0.81 | |
| 4m gait speed (m/s) | 1.38 | 0.18 | 1.07 – 1.79 | 0.01 | |
| BMI (kg/m2) | 1.03 | 0.01 | 1.01 – 1.06 | 0.01 | |
| Home oxygen use | No | 1 | |||
| Yes | 1.27 | 0.35 | 0.74 – 2.17 | 0.39 | |
| COPD exacerbation(s) in previous 12 months | No | 1 | |||
| Yes | 3.12 | 1.87 | 0.96 – 10.11 | 0.06 | |
| Comorbidity present | No | 1 | |||
| Yes | 1.59 | 0.69 | 0.68 – 3.74 | 0.28 | |
Covariates: high to low except for 4m gait speed and BMI where lower gait speed and BMI are associated with increased mortality
BMI = body mass index; FEV1= Forced expiratory volume in one second; MRC = Medical Research Council dyspnoea scale grade