Table 6

Ongoing randomised controlled trials on the effect of vitamin D supplement on the secondary prevention of acute wheeze in preschool and school-age children

Author ClinicalTrials.gov Identifier Setting Age range (years) Phenotype of asthma (n) Oral vitamin D3 dose (IU) Primary outcome measure Expected completion date Comment
Ducharme et al 74 NCT03365687 Canada1–5Viral-induced wheeze (865)100 000 at baseline and at 3.5 months with a daily dose of 400 for 7 months for 7 monthsNumber of asthma attacks treated with oral corticosteroidDecember 2022
Placebo
Celedon et al 75 NCT02687815 USA6–16Asthma treated with inhaled corticosteroids and 25(OH)D <75 nmol/L (400)4000/day for 48 weeksNumber of asthma attacks requiring systemic corticosteroids, or an increase in maintenance dose for at least 3 days or an unplanned healthcare visit due to asthmaNovember 2020Trial has been stopped
Placebo