Baseline characteristics
| Baseline characteristics | All | Low CRF | Normal CRF | High CRF | P value |
| n (%) | 4730 (100) | 745 (15,8) | 3246 (68,6) | 739 (15,6) | |
| Dead, all-cause, n (%) | 4338 (91.7) | 693 (93.0) | 2980 (91.8) | 665 (90.0) | 0.10 |
| Age at inclusion, years, mean (SD) | 48.7 (5.3) | 49.1 (5.2) | 48.6 (5.4) | 48.9 (5.3) | 0.10 |
| CRF, mean (SD) | 33.0 (7.2) | 23.4 (2.5) | 32.5 (4.0) | 44.6 (5.1) | <0.001 |
| Smoking, n (%) | |||||
| Never | 432 (9.1) | 70 (9.4) | 298 (9.2) | 64 (8.7) | <0.001 |
| Former | 931 (19.7) | 178 (23.9) | 640 (19.7) | 113 (15.3) | |
| Active | 3367 (71.2) | 497 (66.7) | 2308 (71.1) | 562 (76.0) | |
| Grams tobacco/day, median (IQR) | 15 (0–21) | 13 (0–21) | 14 (0–21) | 15 (0–23) | <0.001 |
| Self-reported physical activity, n (%) | |||||
| Low | 789 (16.7) | 190 (25.5) | 519 (16.0) | 80 (10.8) | <0.001 |
| Moderate | 3428 (72.5) | 499 (67.1) | 2387 (73.6) | 542 (73.3) | |
| High | 509 (10.8) | 55 (7.4) | 337 (10.4) | 117 (15.8) | |
| BMI, n (%) | |||||
| <20 kg/m2 | 2300 (48.7) | 237 (31.9) | 1581 (48.8) | 482 (65.3) | <0.001 |
| 20–25 kg/m2 | 2129 (45.1) | 395 (53.1) | 1490 (46.0) | 244 (33.1) | |
| >25 kg/m2 | 293 (6.2) | 112 (15.1) | 169 (5.2) | 12 (1.6) | |
| Arterial hypertension, n (%) | 1972 (41.7) | 461 (61.9) | 1332 (41.0) | 179 (24.2) | <0.001 |
| Diabetes mellitus, n (%) | 40 (0.8) | 10 (1.3) | 23 (0.7) | 7 (0.9) | 0.22 |
| Alcohol consumption, n (%) | |||||
| Light (0–2 units/day) | 3881 (82.1) | 568 (76.2) | 2690 (82.9) | 623 (84.3) | <0.001 |
| Moderate (3–5 units/day) | 701 (14.8) | 141 (18.9) | 459 (14.1) | 101 (13.7) | |
| Heavy (>5 units/day) | 148 (3.1) | 36 (4.8) | 97 (3.0) | 15 (2.0) | |
| Socioeconomic status, n (%) | |||||
| Low | 2570 (54.4) | 406 (54.6) | 1755 (54.1) | 409 (55.3) | 0.016 |
| Middle | 1349 (28.6) | 238 (32.0) | 919 (28.4) | 192 (26.0) | |
| High | 805 (17.0) | 100 (13.4) | 567 (17.5) | 138 (18.7) |
BMI, body mass index; CRF, cardiorespiratory fitness; IQR, interquartile range; SD, standard deviation.