Table 4

Parameter estimates and HRs for the final joint Pseudomonas aeruginosa and Aspergillus RTTE hazard model, including model evaluations results from the bootstrap

Parameter descriptionUnitsFinal model estimatesBootstrap resultsHR based on final modelBootstrap resultsRSE (%)
Average95% CIHR95% CI
2.5th percentile97.5th percentile2.5th percentile97.5th percentile
Pseudomonas aeruginosa events
Baseline hazard for
P. aeruginosa event during the first year of study period
1/year0.0950.1180.0130.32572
Effect of first and second
P. aeruginosa event on P. aeruginosa hazard
4.935.263.927.1213819350.6123618
Effect of third P. aeruginosa event on P. aeruginosa hazard6.947.355.819.681033156133515 99814
P. aeruginosa Gompertz hazard within 6 months of study enrolment1/year−0.918−1.02−1.71−0.510.390.360.180.5933
Effect after P. aeruginosa eradication therapy completion−1.93−7.75−85.4−0.240.1450.0004298.42E-380.785250
Aspergillus events
Early baseline hazard of Aspergillus event during the first year of study1/kiloyear78.980.268.095.411
Baseline hazard of Aspergillus event after a year of study period1/kiloyear0.0002530.0003640.0002000.0012980
Effect of second Aspergillus event on Aspergillus hazard13.513.512.214.47.29E+057.33E+051.99E+051.83E+064
Effect of third Aspergillus event on Aspergillus hazard13.313.411.714.55.97E+056.64E+051.21E+052.05E+0611
Aspergillus Gompertz hazard in the first 6 months after enrolment1/year−6470−6129−10653−18840.000.000.000.0042
Aspergillus Gompertz hazard between 0.5 and <1 year of study period1/year−6140−6796−12135−20190.000.000.000.0043
Effect of P. aeruginosa eradication therapy completion on the risk of Aspergillus 1.01.00.381.72.82.71.55.438
  • RSE: relative SE; RTTE, repeated time-to-event.