Table 2

Number and rate of CryoTBB-associated complications with at least possible causal relation

	Total complication rate	Sedation hangover	Pneumothorax	Bleeding moderate	Bleeding severe	Myocardial infarction	Fibrosis exacerbation with death
Premodification (n=19)5
	16 (84%) [62–94%]	3 (16%) [6–38%]	5 (26%) [12–49%]	7 (37%) [19–59%]	8 (42%) [23–64%]	2 (11%) [3–31%]	1 (5%) [1–25%] 29d* (UIP/IPF)
Postmodification (n=42)
	6 (14%) [7–28%]	0 (0%) [0–8%]	5 (12%) [5–25%]	0 (0%) [0–8%]	0 (0%) [0–8%]	0 (0%) [0–8%]	1 (2%) [0–12%] 21d* (UIP/IPF)
P value	<0.001	<0.010	0.160	<0.001	<0.001	0.033	0.559

95% CI given in square brackets.
CryoTBB, transbronchial cryobiopsy; d*, days after intervention; IPF, idiopathic pulmonary fibrosis; UIP, usual interstitial pneumonia; UIP/IPF, histopathology results: UIP; clinical diagnosis: IPF.