Table 2

Changes in measurements from baseline to end of intervention for secondary outcomes at 2 months (tolerance population)

TALIONIRISp value
AHI per hour−11.16 (10.80 ; n=87)***
IQR : −19.00 to −5.00
Median: −11.00
−11.90 (9.43 ; n=69)***
IQR : −17.00 to −7.00
Median: −10.00
0.4025 (†)
Snoring (VAS)−3.70 (2.88 ; n=94)*
IQR : −6.00 to −1.45
Median: −4.00
−4.03 (2.88 ; n=86)*
IQR : −6.65 to −1.30
Median: −3.60
0.4504 (†)
Epworth sleepiness−3.34 (3.77 ; n=95)***
IQR : −6.00 to −1.00
Median: −3.00
−3.76 (4.16 ; n=87)***
IQR : −7.00 to −2.00
Median: −3.00
0.2143 (†)
Pichot fatigue−5.12 (6.97 ; n=81)***
IQR : −9.00 to −1.00
Median: −4.00
−7.52 (7.22 ; n=60)***
IQR : −14.00 to −2.00
Median: −6.00
0.0544 (†)
Pichot depression−1.44 (3.23 ; n=79)**
IQR : −3.00 to 0.00
Median: −1.00
−2.12 (3.31 ; n=59)***
IQR : −4.00 to 0.00
Median: −1.00
0.2240 (†)
SF-12 Mental score5.27 (17.68 ; n=81)**
IQR : −7.91 to 18.31
Median: 6.59
9.07 (21.25; n=60)***
IQR : −4.0 to 22.57
Median: 8.39
0.4441 (†)
SF-12 physical score4.22 (14.81 ; n=81)*
IQR : −6.23 to 12.10
Median: 5.21
7.71 (13.02 ; n=60)***
IQR : 0.72 to 14.55
Median: 5.96
0.2967 (†)
Diastolic blood pressure
(patients with hypertension at inclusion)
−7.04 (10.85 ; n=26)**
IQR : −13.00 to −4.00
Median: −7.50
−4.84 (12.80 ; n=25)
IQR : −10.00 to 5.00
Median: −5.00
0.3796 (W)
Systolic blood pressure
(patients with hypertension at inclusion)
−11.19 (16.07 ; n=26)***
IQR : −17 .00 to −5.00
Median: −9.00
−4.36 (17.42 ; n=17)
IQR : −18.00 to 5.00
Median: −4.00
0.2091 (W)
  • Data are mean (SD; number of patients) and median [IQR]. (†) ANCOVA; (W) Wilcoxon test; significance of evolution from baseline: *p<0.05; **p<0.01; ***p<0.0001 (paired t-test).

  • AHI, apnoea–hypopnoae index; ANCOVA, analysis of covariance; Snoring, Epworth and pressure (systolic and diastolic) were analysed using the Last Observation Carried Forward method;VAS, visual analogue scale.