Table 2

Results of serial cross-sectional analysis of SHBG, TT or BT on asthma (using multiple imputation) adjusted for previous measures of asthma and sex hormones (where available) at five time points in a subsample of 512 males in ALSPAC

Age at sex hormone exposure (years)Age at asthma outcome (years)OR* (95% CI) SHBGn with data for SHBG (% missing)†OR* (95% CI) total testosteronen with data for total testosterone (% missing)†OR* (95% CI) bioavailable testosteronen with data for bioavailable testosterone (% missing)n after multiple imputation
9.910.70.96 (0.74 to 1.24)381 (26)1.12 (0.87 to 1.43)381 (26)1.02 (0.77 to 1.34)381 (26)512
11.813.11.54 (0.71 to 3.37)339 (34)0.85 (0.55 to 1.32)338 (34)0.79 (0.47 to 1.34)338 (34)512
13.813.81.32 (0.64 to 2.70)318 (38)0.80 (0.46 to 1.38)315 (38)0.86 (0.48 to 1.55)315 (38)512
15.516.51.18 (0.67 to 2.06)263 (49)0.89 (0.59 to 1.35)262 (49)0.87 (0.56 to 1.35)262 (49)512
17.822.91.02 (0.57 to 1.83)144 (72)0.71 (0.43 to 1.16)99 (81)0.87 (0.54 to 1.41)99 (81)512
  • *OR for asthma per SD increase in either SHBG, TT or BT.

  • †n refers to the number of individuals with complete data in the analysis of specified hormone (before multiple imputation). Per cent missing refers to the fraction of individuals missing some data (either asthma measurements, hormone measurements or covariates, where covariates include any previous measurement of asthma and hormone) at each time point, which were subject to multiple imputation.

  • ALSPAC, Avon Longitudinal Study of Parents and Children; BT, bioavailable testosterone; SHBG, sex hormone-binding globulin; TT, total testosterone.