Cumulative EU-years | ∆FEV1 (mL/year) | ∆FVC (mL/year) | ∆FEV1/FVC (%/year) | |||
β (95% CI) * | P values | β (95% CI) * | P values | β (95% CI) * | P values | |
Biological dust | 0.1 (−0.04 to 0.3) | 0.14 | 0.1 (−0.1 to 0.4) | 0.29 | −0.0 (−0.003 to 0.003) | 0.99 |
Mineral dust | 0.1 (−0.1 to 0.2) | 0.21 | 0.2 (−0.03 to 0.4) | 0.09 | −0.0 (0.003 to 0.002) | 0.62 |
Gases/fumes | −0.1 (−0.3 to − 0.1) | 0.04 | −0.2 (−0.4 to 0.1) | 0.17 | −0.0 (0.002 to 0.002) | 0.79 |
Fungicides | 0.2 (−0.2 to 0.5) | 0.41 | 0.7 (0.2 to 1.3) | 0.01 | −0.0 (−0.006 to 0.006) | 0.93 |
Herbicides | 0.3 (−0.1 to 0.7) | 0.14 | 0.6 (−0.03 to 1.3) | 0.06 | 0.003 (−0.005 to 0.1) | 0.51 |
Insecticides | 0.1 (−0.2 to 0.4) | 0.57 | 0.6 (0.1 to 1.1) | 0.01 | −0.0 (−0.006 to 0.005) | 0.89 |
Aromatic solvents | −0.6 (−1.0 to −0.3) | 0.002 | −0.9 (−1.6 to −0.4) | 0.002 | 0.003 (−0.004 to 0.01) | 0.38 |
Chlorinated solvents | −0.1 (−0.3 to 0.1) | 0.18 | −0.1 (0.4 to 0.2) | 0.47 | −0.001 (0.004 to 0.001) | 0.42 |
Other solvents | −0.1 (0.4 to 0.2) | 0.49 | −0.3 (−0.8 to 0.1) | 0.14 | 0.001 (0.003 to 0.01) | 0.65 |
Metals | −0.1 (0.2 to 0.1) | 0.65 | −0.1 (−0.3 to 0.3) | 0.93 | −0.002 (−0.004 to 0.001) | 0.22 |
*Adjusted for sex, height, smoking, pack-years, childhood and adulthood socioeconomic status, childhood and adulthood asthma and sampling weights; the models with exposures to biological dust, mineral dust, gases/fumes and VGDF were additionally adjusted for all types of pesticides, the models with exposures to fungicides, herbicides and insecticides were additionally adjusted for vapour, gases, dust and fumes (VGDF), and the models with exposures to solvents and metals were additionally adjusted for all types of pesticides and VGDF.