Table 1

Richness, alpha diversity and relative abundance by nasal airway microbiota profiles at age 2 months

Nasal microbiota profile at age 2 monthsP value
Moraxella dominant, n=255 (30.4%) Streptococcus dominant, n=188 (22.4%) Dolosigranulum dominant, n=188 (22.4%) Staphylococcus dominant, n=150 (17.9%) Corynebacteriaceae dominant, n=58 (6.9%)
Richness
 Number of OTUs, median (IQR)10 (6–16)33 (25–44)19 (14–26)24 (16–33)25 (20–37)<0.001
Alpha diversity
 Shannon Index, median (IQR)0.45 (0.23–0.75)1.66 (1.23–2.07)1.01 (0.76–1.31)0.99 (0.72–1.35)1.15 (0.79–1.47)<0.001
Relative abundance of 10 most abundant genera
 Mean (SD)
 Moraxella 0.84 (0.16)0.01 (0.03)0.01 (0.06)0.01 (0.05)0.00 (0.01)<0.001*
 Dolosigranulum 0.05 (0.08)0.02 (0.06)0.63 (0.18)0.01 (0.05)0.04 (0.09)<0.001*
 Staphylococcus 0.02 (0.04)0.10 (0.10)0.03 (0.08)0.68 (0.19)0.05 (0.07)<0.001*
 Streptococcus 0.04 (0.08)0.45 (0.23)0.07 (0.08)0.11 (0.10)0.09 (0.09)<0.001*
 Corynebacteriaceae genus 10.02 (0.03)0.01 (0.04)0.15 (0.12)0.02 (0.07)0.46 (0.32)<0.001*
 Corynebacteriaceae genus 20.01 (0.02)0.09 (0.17)0.03 (0.07)0.05 (0.10)0.17 (0.25)<0.001*
 Neisseriaceae genus 10.01 (0.06)0.06 (0.18)0.02 (0.07)0.02 (0.09)0.06 (0.19)<0.001*
 Gemella 0.00 (0.01)0.04 (0.05)0.01 (0.01)0.02 (0.04)0.02 (0.06)<0.001*
 Haemophilus 0.01 (0.06)0.03 (0.11)0.01 (0.02)0.01 (0.04)0.03 (0.13)0.05*
 Veillonella 0.00 (0.00)0.02 (0.04)0.00 (0.01)0.01 (0.02)0.01 (0.02)<0.001*
 Range
 Moraxella 0.35–1.000.00–0.340.00–0.420.00–0.430.00–0.09
 Dolosigranulum 0.00–0.430.00–0.370.19–0.940.00–0.340.00–0.38
 Staphylococcus 0.00–0.280.00–0.470.00–0.440.20–0.990.00–0.28
 Streptococcus 0.00–0.480.00–0.960.00–0.440.00–0.390.00–0.39
 Corynebacteriaceae genus 10.00–0.210.00–0.390.00–0.510.00–0.430.00–0.97
 Corynebacteriaceae genus 20.00–0.140.00–0.780.00–0.460.00–0.570.00–0.94
 Neisseriaceae genus 10.00–0.500.00–0.920.00–0.530.00–0.640.00–0.78
 Gemella 0.00–0.090.00–0.480.00–0.060.00–0.430.00–0.47
 Haemophilus 0.00–0.640.00–0.990.00–0.230.00–0.470.00–0.97
 Veillonella 0.00–0.030.00–0.250.00–0.090.00–0.090.00–0.08

  • *Benjamini-Hochberg false-discovery rate adjusted p value accounting for multiple comparisons.

  • OTU, operational taxonomic unit.