Table 1

Summary of meta-analyses

OutcomeNumber of studiesNumber of participantsEffect size (modelling strategy)Pooled effect size and CII2, %
Exacerbations leading to hospitalisation61873Std. mean difference (IV, random effects, 95% CI)−0.19 (−0.35 to –0.04)0
Exacerbations leading to emergency department (ED) visits133883OR (IV, random effects, 95% CI)0.70 (0.53 to 0.92)26
Absence from school104609Std. mean difference (IV, random effects, 95% CI)−0.07 (−0.22 to 0.08)70
Days of restricted activity31852Std. mean difference (IV, random effects, 95% CI)−0.30 (−0.41 to –0.18)0
  • IV, inverse variance.