Table 2

Observed and expected second and higher order primary cancers over the entire 335 436 patient-years of follow-up from 6 months after diagnosis to 10 years follow-up or the 31 December 2014, overall, by subsite of first primary lung cancer and by patient characteristics. Italics denotes the lung sub-sites

Observed SPCsExpected SPCsAbsolute incidence rate per 100 000 person-yearsStandardised incidence rate ratio
Estimate(95% CI)Estimate(95% CI)
Overall23131491.9689.6(661.7 to 718.2)1.55(1.49 to 1.61)
Subsite of first primary lung cancerSmall cell carcinoma131109.0455.3(380.7 to 540.2)1.20(1.00 to 1.43)
Adenocarcinoma759407.0752.4(699.8 to 807.9)1.86(1.73 to 2.00)
Squamous cell carcinoma (SCC)873497.9882.8(825.2 to 943.3)1.75(1.64 to 1.87)
Other NSCLC312223.0619.4(552.6 to 692.1)1.40(1.25 to 1.56)
Carcinoid3141.7219.4(149.1 to 311.4)0.74(0.51 to 1.06)
Unspecified lung207213.2488.3(424.0 to 559.5)0.97(0.84 to 1.11)
Site of SPCLung1460993.8435.3(413.2 to 458.2)1.47(1.39 to 1.55)
Small cell carcinoma 14294.342.3(35.7 to 49.9)1.51(1.27 to 1.78)
NSCLC 1318899.5392.9(372.0 to 414.7)1.47(1.39 to 1.55)
  Adenocarcinoma 485187.8144.6(132.0 to 158.0)2.58(2.36 to 2.82)
  Squamous cell carcinoma 400190.9119.2(107.8 to 131.5)2.10(1.90 to 2.31)
  Other NSCLC 216143.564.4(56.1 to 73.6)1.51(1.31 to 1.72)
  Carcinoid 134.43.9(2.1 to 6.6)2.98(1.59 to 5.10)
  Unspecified lung 204372.960.8(52.8 to 69.8)0.55(0.47 to 0.63)
Bladder397299.9118.4(107.0 to 130.6)1.32(1.20 to 1.46)
Oesophageal SCC12452.137.0(30.7 to 44.1)2.38(1.98 to 2.84)
Laryngeal12243.536.4(30.2 to 43.4)2.81(2.33 to 3.35)
Head and neck210102.662.6(54.4 to 71.7)2.05(1.78 to 2.34)
Age at diagnosis30–495917.5316.1(240.6 to 407.8)3.38(2.57 to 4.35)
50–59332121.0608.3(544.6 to 677.3)2.74(2.46 to 3.05)
60–69862428.0779.0(727.8 to 832.7)2.01(1.88 to 2.15)
70–79833658.9751.4(701.2 to 804.2)1.26(1.18 to 1.35)
80–99227266.4558.1(487.9 to 635.6)0.85(0.74 to 0.97)
SexMale13981030.7792.7(751.7 to 835.4)1.36(1.29 to 1.43)
Female915461.1575.2(538.5 to 613.7)1.98(1.86 to 2.12)
Deprivation quintile1-least deprived315234.4616.1(549.9 to 688.0)1.34(1.20 to 1.50)
2391273.5653.7(590.5 to 721.8)1.43(1.29 to 1.58)
3464303.2688.4(627.2 to 754.0)1.53(1.39 to 1.68)
4492325.1663.9(606.5 to 725.2)1.51(1.38 to 1.65)
5 - most deprived651355.6784.5(725.4 to 847.2)1.83(1.69 to 1.98)
Period of first diagnosis2000–2004762535.8633.3(589.2 to 680.0)1.42(1.32 to 1.53)
2005–2009941575.2724.6(679.1 to 772.5)1.64(1.53 to 1.74)
2010–2014610380.9715.4(659.8 to 774.5)1.60(1.48 to 1.73)
Elapsed follow-up time6–12 months390450.9401.4(362.5 to 443.3)0.87(0.78 to 0.96)
1–5 years1302804.8698.9(661.4 to 737.9)1.62(1.53 to 1.71)
5–10 years621236.21194.9(1102.7 to 1292.6)2.63(2.43 to 2.84)