Table 2

Univariate and multivariate Cox proportional hazards analysis of CPI and clinicopathological parameters for DFS and OS in MDA cohort

Training cohortMDA
n (%)
DFS*OS†
Univariate analysisMultivariate analysisUnivariate analysisMultivariate analysis
HR (95% CI)P valuesHR (95% CI)P valuesHR (95% CI)P valuesHR (95% CI)P values
CPI <0.001 <0.001 <0.001 <0.001
 Low78 (66.7%)1111
 High39 (33.3%)4.04 (2.22 to 7.38)4.12 (2.26 to 7.51)3.23 (1.81 to 5.77)3.1 (1.71 to 5.62)
Gender0.2320.1750.562
 Male71 (60.7%)111
 Female46 (39.3%)0.68 (0.36 to 1.28)0.64 (0.34 to 1.22)0.84 (0.46 to 1.52)
Age (years)0.3230.378
 <658 (6.8%)11
 ≥65109 (93.2%)0.60 (0.21 to 1.67)0.63 (0.23 to 1.76)
Adjuvant treatment0.6230.751
 No67 (57.3%)11
 Yes45 (38.5%)1.35 (0.74 to 2.48)1.25 (0.69 to 2.31)
 Unknown5 (4.2%)
Tobacco0.7150.1680.528
 Former60 (51.3%)111
 Current57 (48.7%)1.12 (0.62 to 2.02)1.51 (0.84 to 2.70)1.21 (0.67 to 2.20)
  • *Events/n=44/117.

  • Events/n=46/117.

  • CPI, combined prognostic index; DFS, disease-free survival; OS, overall survival.

  • Significant p values are highlighted in bold letters.