Univariate and multivariate Cox proportional hazards analysis of CPI and clinicopathological parameters for DFS and OS in MDA cohort
| Training cohort | MDA n (%) | DFS* | OS† | ||||||
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | ||||||
| HR (95% CI) | P values | HR (95% CI) | P values | HR (95% CI) | P values | HR (95% CI) | P values | ||
| CPI | <0.001 | <0.001 | <0.001 | <0.001 | |||||
| Low | 78 (66.7%) | 1 | 1 | 1 | 1 | ||||
| High | 39 (33.3%) | 4.04 (2.22 to 7.38) | 4.12 (2.26 to 7.51) | 3.23 (1.81 to 5.77) | 3.1 (1.71 to 5.62) | ||||
| Gender | 0.232 | 0.175 | 0.562 | ||||||
| Male | 71 (60.7%) | 1 | 1 | 1 | |||||
| Female | 46 (39.3%) | 0.68 (0.36 to 1.28) | 0.64 (0.34 to 1.22) | 0.84 (0.46 to 1.52) | |||||
| Age (years) | 0.323 | 0.378 | |||||||
| <65 | 8 (6.8%) | 1 | 1 | ||||||
| ≥65 | 109 (93.2%) | 0.60 (0.21 to 1.67) | 0.63 (0.23 to 1.76) | ||||||
| Adjuvant treatment | 0.623 | 0.751 | |||||||
| No | 67 (57.3%) | 1 | 1 | ||||||
| Yes | 45 (38.5%) | 1.35 (0.74 to 2.48) | 1.25 (0.69 to 2.31) | ||||||
| Unknown | 5 (4.2%) | ||||||||
| Tobacco | 0.715 | 0.168 | 0.528 | ||||||
| Former | 60 (51.3%) | 1 | 1 | 1 | |||||
| Current | 57 (48.7%) | 1.12 (0.62 to 2.02) | 1.51 (0.84 to 2.70) | 1.21 (0.67 to 2.20) | |||||
*Events/n=44/117.
†Events/n=46/117.
CPI, combined prognostic index; DFS, disease-free survival; OS, overall survival.
Significant p values are highlighted in bold letters.