Table 1

Univariate and multivariate Cox proportional hazards analysis of PI and clinicopathological parameters for DFS and OS in the MDA cohort

Training cohortMDA
n (%)
DFS*OS†
Univariate analysisMultivariate analysisUnivariate analysisMultivariate analysis
HR (95% CI)P valuesHR (95% CI)P valuesHR (95% CI)P valuesHR (95% CI)P values
PI <0.001 <0.001 0.003 0.004
 Low78 (66.7%)1111
 High39 (33.3%)3.5 (1.94 to 6.40)4.06 (2.18 to 7.56)2.39 (1.34 to 4.27)2.38 (1.32 to 4.31)
Stage <0.001 <0.001 0.023 0.064
 I50 (42.7%)1111
 II37 (31.6%)1.25 (0.56 to 2.80)0.5771.54 (0.68 to 3.50)0.3000.89 (0.42 to 1.86)0.7531.02 (0.48 to 2.16)0.952
 III30 (25.7%)3.83 (1.87 to 7.86) <0.001 4.09 (1.96 to 8.53) <0.001 2.19 (1.12 to 4.30) 0.022 2.09 (1.06 to 4.14) 0.034
Gender0.2320.2160.562
 Male71 (60.7%)111
 Female46 (39.3%)0.68 (0.36 to 1.28)0.66 (0.35 to 1.27)0.84 (0.46 to 1.52)
Age (years)0.3230.378
 <658 (6.8%)11
 ≥65109 (93.2%)0.60 (0.21 to 1.67)0.63 (0.23 to 1.76)
Adjuvant treatment0.6230.751
 No67 (57.3%)11
 Yes45 (38.5%)1.35 (0.74 to 2.48)1.25 (0.69 to 2.31)
 Unknown5 (4.2%)
Tobacco0.7150.1680.259
 Former60 (51.3%)111
 Current57 (48.7%)1.12 (0.62 to 2.02)1.51 (0.84 to 2.70)1.41 (0.78 to 2.55)
  • *Events/n=44/117.

  • †Events/n=46/117.

  • DFS, disease-free survival; OS, overall survival; PI, prognostic index.

  • Significant p values are highlighted in bold letters.