Table 2

Blue module pathway enrichment analysis using Innate DB (top 15 enriched pathways)

Pathway nameFDRGene symbols
IL-4 signalling0.01JAK1; PTPN6
LIF signalling TSLP<0.0001CREBBP; JAK1
DBNL; DOCK5; JAK1; KDM3B; LYN; PTPN6; STK10; WIPF1; ZZEF1
BCR<0.0001ATP2B4; CHST15; DBNL; LCP2; LYN; PTPN6; RAPGEF1; RPS6KA1; SH3BP2
TCR<0.0001CREBBP; DBNL; DIAPH1; ELMO1; LCP2; LYN; PTPN6; RAPGEF1; SH2D3C; SH3BP2; WIPF1
IL-5<0.001JAK1; LYN; PTPN6; RAPGEF1; RPS6KA1
IL-40.01CREBBP; JAK1; PTPN6; SPI1
EGFR10.01ACTN4; EPS15L1; IQGAP1; JAK1; LYN; PTPN6; PTPRE; RPS6KA1; SH2D3C
IL-30.01JAK1; LYN; PTPN6; RAPGEF1
RANKL0.01JAK1; LYN; PTPN6; SPI1
Kit receptor0.016 LYN; PTPN6; RPS6KA1; WIPF1
Prolactin0.016CREBBP; JAK1; LYN; PTPN6
IL-20.029JAK1; LYN; PTPN6
IL-60.03CREBBP; JAK1; LYN
IL-110.04JAK1; RPS6KA1
  • BCR, B-cell receptor; EGFR, epidermal growth factor receptor; FDR, false discovery rate; IL, interleukin; LIF, leukaemia inhibitory factor; RANKL, receptor activator of nuclear factor kappa-Β ligand; TCR, T-cell receptor; TSLP, thymic stromal lymphopoietin.