Factors associated with mean benefit per day of life measured in utility
| Univariate | Multivariate predictive | Multivariate explanatory | |||||||
| Coefficient | 95% CI | P values | Coefficient | 95% CI | P values | Coefficient | 95% CI | P values | |
| Predictive variables | |||||||||
| Age | 0 | −0.002 to 0.002 | 0.94 | ||||||
| Male gender | −0.008 | −0.053 to 0.037 | 0.71 | ||||||
| Zubrod 2–4 vs 0–1 | 0.009 | −0.034 to 0.052 | 0.69 | ||||||
| Baseline utility | −0.478 | −0.596 to −0.360 | <0.001* | ||||||
| Baseline Borg | 0.019 | 0.011 to 0.027 | <0.001 | 0.022 | 0.014 to 0.030 | <0.001 | 0.012 | 0.007 to 0.018 | <0.001 |
| Urgent/emergent vs elective | 0.026 | −0.027 to 0.079 | 0.33 | ||||||
| Time from diagnosis to procedure (weeks) | −0.00006 | −0.00017 to 0.00005 | 0.77 | ||||||
| Comorbidities | |||||||||
| COPD | 0.009 | −0.054 to 0.073 | 0.77 | ||||||
| Cardiovascular | 0.002 | −0.048 to 0.053 | 0.92 | ||||||
| Diabetes | 0.027 | −0.024 to 0.079 | 0.29 | ||||||
| Second primary solid tumour | −0.016 | −0.087 to 0.054 | 0.65 | ||||||
| Cancer type | |||||||||
| Lung | 0.028 | −0.016 to 0.072 | 0.21 | ||||||
| Other malignancies | <ref> | ||||||||
| Initial treatment type | |||||||||
| Surgery | −0.016 | −0.069 to 0.038 | 0.57 | ||||||
| Chemotherapy | −0.019 | −0.077 to 0.039 | 0.52 | ||||||
| Radiation therapy | 0.015 | −0.057 to 0.086 | 0.68 | ||||||
| No treatment | <ref> | ||||||||
| Any prior therapeutic bronchoscopy | −0.087 | −0.16 to −0.007 | 0.03 | ||||||
| Indication(s) for therapeutic bronchoscopy* | |||||||||
| Tracheoesophageal fistula | −0.064 | −0.176 to 0.048 | 0.26 | ||||||
| Haemoptysis | 0.009 | −0.045 to 0.063 | 0.73 | ||||||
| Number of bronchopulmonary segments obstructed | −0.003 | −0.007 to 0.001 | 0.20 | −0.006 | −0.010 to −0.002 | 0.006 | −0.003 | −0.006 to −0.0002 | 0.036 |
| Location of most proximal obstruction | |||||||||
| Trachea | −0.027 | −0.010 to 0.045 | 0.46 | ||||||
| Bilateral mainstem | −0.047 | −0.146 to 0.053 | 0.36 | ||||||
| Right mainstem | 0.032 | −0.038 to 0.101 | 0.37 | ||||||
| Left mainstem | −0.023 | −0.099 to 0.053 | 0.55 | ||||||
| Right bronchus intermedius | 0.026 | −0.060 to 0.094 | 0.55 | ||||||
| Lobar only | <ref> | ||||||||
| Obstruction type of most proximal location | |||||||||
| Endobronchial | <ref> | ||||||||
| Extrinsic | −0.043 | −0.093 to 0.007 | 0.09 | ||||||
| Mixed | −0.031 | −0.102 to 0.040 | 0.39 | ||||||
| Explanatory variables | |||||||||
| ∆Borg at day-7 | −0.023 | −0.035 to −0.011 | <0.001 | ||||||
| ∆Utility at day-7 | 0.693 | 0.581 to 0.805 | <0.001 | 0.612 | 0.498 to 0.725 | <0.001 | |||
| Ventilation type | |||||||||
| Jet ventilation | −0.005 | −0.078 to 0.069 | 0.90 | ||||||
| Volume cycled | <ref> | ||||||||
| Bronchoscopy type | |||||||||
| Rigid and flexible | −0.019 | −0.100 to 0.062 | 0.65 | ||||||
| Flexible only | <ref> | ||||||||
| Treatment modalities | |||||||||
| Any laser | 0.01 | −0.049 to 0.068 | 0.75 | ||||||
| Electrocautery | 0.047 | 0.001 to 0.094 | 0.04 | ||||||
| Argon plasma | 0.007 | −0.038 to 0.052 | 0.76 | ||||||
| Cryorecanalisation | 0.081 | 0.030 to 0.133 | 0.002 | ||||||
| Microdebrider | −0.004 | −0.1 | 0.88 | ||||||
| Rigid ‘coring’ | 0.038 | −0.032 to 0.108 | 0.29 | ||||||
| Dilation | −0.042 | −0.097 to 0.012 | 0.13 | ||||||
| Stent at first procedure | −0.035 | −0.081 to 0.011 | 0.14 | ||||||
| Technical success | |||||||||
| Complete or partial | 0.003 | −0.068 to 0.073 | 0.94 | ||||||
| Failed | <ref> | ||||||||
| Postprocedure treatment | |||||||||
| Surgery | −0.058 | −0.170 to 0.054 | 0.31 | ||||||
| Chemotherapy | 0.004 | −0.041 to 0.048 | 0.87 | ||||||
| Radiation therapy | 0.004 | −0.040 to 0.048 | 0.87 | ||||||
↵*Plot of residuals vs fitted values and White’s tests indicate significant heteroscedasticity; values reported but not used in multivariate model.