Table 3

Examination of individual characteristics of the five patients who had the greatest improvements and the five patients who had the most pronounced worsening of T90 following morphine

Rand numberΔ T90
(% TST)
Δ AHI
(/hour)
Age (years)ABCB1
genotype
OPRM1
genotype
HTR3B genotypePlacebo VRT
(mmHg)
Placebo HCVR
(mmHg/L/min)
Greatest improvements in T90 R53 −15.7−30.754C/CA/G CT62.874.05
R62 −8.4−22.649C/CA/G CC54.381.66
R43 −6.113.961T/TA/G CC49.860.94
R50 −2.9−24.864C/TA/ACC60.940.93
R38 −1.9−0.663C/TA/G TT42.371.59
Mean
(SD)
−7.0
(5.5)
13.0
(18.9)
58.2
(6.5)
3/5
(C/T+T/T)
4/5
A/G
2/5
(CT+TT)
54.10
(8.4)
1.80
(1.3)
5 patients with worst T90 change R31 3.39.163C/CA/ACC56.952.09
R34 3.84.243C/CA/GCT44.561.90
R33 4.627.755C/TA/ACT42.172.53
R36 20.518.233T/TA/ACT45.212.06
R64 20.9−1.650C/CA/ACT59.030.42
Mean
(SD)
10.6
(9.2)
11.5
(11.6)
48.8
(11.5)
2/5 (C/T+T/T)1/5
A/G
4/5
(CT+TT)
49.60
(7.8)
1.80
(0.8)
50 remaining patients Mean
(SD)
0.1
(0.6)
1.9
(11.2)
42.6
(11.2)
T/T=17
C/T=19
C/C=24
A/A=44
A/G=16
CC=36
CT=23
TT=1
54.60
(6.9)
1.60
(0.8)