Examination of individual characteristics of the five patients who had the greatest improvements and the five patients who had the most pronounced worsening of T90 following morphine
| Rand number | Δ T90 (% TST) | Δ AHI (/hour) | Age (years) | ABCB1 genotype | OPRM1 genotype | HTR3B genotype | Placebo VRT (mmHg) | Placebo HCVR (mmHg/L/min) | |
| Greatest improvements in T90 | R53 | −15.7 | −30.7 | 54 | C/C | A/G | CT | 62.87 | 4.05 |
| R62 | −8.4 | −22.6 | 49 | C/C | A/G | CC | 54.38 | 1.66 | |
| R43 | −6.1 | 13.9 | 61 | T/T | A/G | CC | 49.86 | 0.94 | |
| R50 | −2.9 | −24.8 | 64 | C/T | A/A | CC | 60.94 | 0.93 | |
| R38 | −1.9 | −0.6 | 63 | C/T | A/G | TT | 42.37 | 1.59 | |
| Mean (SD) | −7.0 (5.5) | 13.0 (18.9) | 58.2 (6.5) | 3/5 (C/T+T/T) | 4/5 A/G | 2/5 (CT+TT) | 54.10 (8.4) | 1.80 (1.3) | |
| 5 patients with worst T90 change | R31 | 3.3 | 9.1 | 63 | C/C | A/A | CC | 56.95 | 2.09 |
| R34 | 3.8 | 4.2 | 43 | C/C | A/G | CT | 44.56 | 1.90 | |
| R33 | 4.6 | 27.7 | 55 | C/T | A/A | CT | 42.17 | 2.53 | |
| R36 | 20.5 | 18.2 | 33 | T/T | A/A | CT | 45.21 | 2.06 | |
| R64 | 20.9 | −1.6 | 50 | C/C | A/A | CT | 59.03 | 0.42 | |
| Mean (SD) | 10.6 (9.2) | 11.5 (11.6) | 48.8 (11.5) | 2/5 (C/T+T/T) | 1/5 A/G | 4/5 (CT+TT) | 49.60 (7.8) | 1.80 (0.8) | |
| 50 remaining patients | Mean (SD) | 0.1 (0.6) | 1.9 (11.2) | 42.6 (11.2) | T/T=17 C/T=19 C/C=24 | A/A=44 A/G=16 | CC=36 CT=23 TT=1 | 54.60 (6.9) | 1.60 (0.8) |