Table 3

Representative biological functions for each module based on enrichment map clustering of gene ontology: biological process and Reactome terms

ModuleExpression in diseaseNo genes in moduleBiological function
ME1UP1579Cilia organisation
ME2DOWN1404Blood vessel development
ME3UP396Extracellular Matrix organisation
ME4UP380Cell division/DNA replication/DNA repair
ME5UP371B-cell activation/unfolded protein response
ME6UP207Extracellular Matrix organisation
ME7DOWN204Leucocyte activation/degranulation
ME8DOWN188Cellular metabolic process
ME9DOWN163Response to bacteria/apoptosis/RNA transcription
ME10DOWN158Surfactant metabolism
ME11DOWN116T-cell activation/Major histocompatability complex (MHC) class I activity/interferon response
ME12DOWN107Leucocyte activation/degranulation
ME13DOWN80Muscle contraction/organ development
ME14UP75Contractile fibre/cell-extracellular matrix interactions
ME15DOWN58Cellular protein catabolic mechanism
ME16DOWN39Cell-cell junction organisation