Variable | OR (95% CI) | P values |

FEV_{1}% predicted (baseline) | 0.92 (0.8911 to 0.9601) | <0.001 |

Shannon index <1 | 0.23 (0.0593 to 0.9270) | 0.039 |

In the univariate analysis, covariates such as Shannon’s and Simpson’s diversity indices, FVC, body mass index (BMI), relative abundance (RA) of

*Pseudomonas*at 50% and 75%, Simpson index >0.5 and RA of*Streptococcus*at 25% were significantly associated with the primary outcome and then were considered for the multivariable logistic regression model. However, in the final model, those were not significant (p>0.05) and thus removed. The final model (n=104) had good calibration (goodness of fit p=0.99) and discrimination (area under the receiver operating characteristic (ROC) curve=0.92).CF, cystic fibrosis; eESLD, early end-stage lung disease.