Positive predictive values of test combinations derived from the three-test, random effects model in specified subgroups (TSPOT positive at the international cut-off of ≥6 spots)
| Test combination (TST/QFT-IT/TSPOT) | Foreign-born, HIV-seronegative, aged ≥5 years, % (95 % credible intervals) | Foreign-born, HIV-seronegative, aged <5 years, % (95 % credible intervals) | Foreign-born, HIV-seropositive, aged ≥5 years, % (95 % credible intervals) | US-born, HIV-seronegative, aged ≥5 years, % (95 % credible intervals) | US-born, HIV-seropositive, aged ≥5 years, % (95 % credible intervals) |
| – – – | 4.8 (0.1 to 11.8) | 0.5 (0 to 2.1) | 12.7 (0 to 26.6) | 2.1 (0 to 6.3) | 0.6 (0 to 1.7) |
| – – + | 58.3 (15.5 to 75.0) | NA | NA | 50.2 (0 to 100) | 34.7 (0 to 77.8) |
| – + – | 69.6 (16.2 to 96.8) | NA | 50.0 (0 to 100) | 44.3 (10.0 to 85.0) | 12.9 (1.9 to 28.3) |
| – + + | 98.2 (93.3 to 100) | NA | NA | 98.7 (91.7 to 100) | 93.7 (70.0 to 100) |
| + – – | 8.2 (1.7 to 13.0) | 1.2 (0 to 4.3) | 30.1 (0 to 70.0) | 11.4 (1.9 to 26.4) | 8.4 (0 to 22.5) |
| + – + | 82.2 (68.0 to 88.3) | NA | NA | 92.8 (60.0 to 100) | NA |
| + + – | 91.1 (73.9 to 99.2) | 66.0 (16.7 to 100) | 82.2 (0 to 100) | 92.0 (71.4 to 100) | 75.3 (37.5 to 100) |
| + + + | 99.6 (98.8 to 100) | 99.2 (88.9 to 100) | 94.0 (5.0 to 100) | 100 (98.7 to 100) | 99.7 (93.3 to 100) |
The positive predictive values represent the estimated likelihood that an individual with the given test combination has latent TB infection; 95% credible intervals are listed in parentheses after each point estimate; cells in which <5 participants in the group had the listed test combination are listed as NA.
NA, not applicable; QFT-IT, QuantiFERON Gold In-Tube; TSPOT, T-SPOT.TB; TST, tuberculin skin test.