Table 3

Associations between occupational exposures and COPD incidence, stratified by intensity of exposure

Cases in unexposed (%)Cases in ever
low-exposed (%)
Cases in ever
high-exposed (%)
Relative risk (95% CI),
ever low vs no exposure
Relative risk (95% CI),
ever high vs no exposure
Biological dust55/2264 (2.4)31/905 (3.4)10/174 (5.7)1.5 (1.0 to 2.2)2.2 (1.2 to 4.0)
Mineral dust65/2501 (2.6)18/554 (3.2)13/288 (4.5)1.0 (0.6 to 1.7)1.3 (0.7 to 2.2)
Gases and fumes41/1888 (2.2)45/1102 (4.1)10/353 (2.8)1.6 (1.1 to 2.5)1.0 (0.5 to 1.9)
Vapours, gases, dusts and fumes40/1725 (2.3)35/1067 (3.3)21/551 (3.8)1.3 (0.8 to 2.0)1.3 (0.8 to 2.3)
Herbicides91/3269 (2.8)1/49 (2.0)4/25 (16.0)0.5 (0.0 to 3.0)2.8 (1.0 to 5.9)
Insecticides88/3229 (2.7)3/54 (5.6)5/60 (8.3)2.0 (0.5 to 5.2)2.2 (0.8 to 4.5)
Fungicides88/3211 (2.7)4/72 (5.6)4/60 (6.7)1.5 (0.5 to 3.7)2.0 (0.7 to 4.6)
All pesticides86/3179 (2.7)5/94 (5.3)5/70 (7.1)2.0 (0.7 to 4.4)2.1 (0.8 to 4.3)
Aromatic solvents80/2796 (2.9)14/495 (2.8)2/52 (3.8)0.8 (0.5 to 1.4)1.3 (0.2 to 4.6)
Chlorinated solvents83/2904 (2.9)9/320 (2.8)4/119 (3.4)0.8 (0.4 to 1.6)0.7 (0.2 to 1.7)
Other solvents71/2391 (3.0)22/883 (2.5)3/69 (4.3)0.8 (0.5 to 1.2)1.4 (0.4 to 4.0)
Metals82/2922 (2.8)10/287 (3.5)4/134 (3.0)1.0 (0.5 to 1.9)0.7 (0.2 to 1.7)
  • Relative risks adjusted for sex, age, pack-years of smoking, FEV1/FVC ratio at baseline (%predicted), socioeconomic status and early life disadvantage score.