Table 4

Estimated prevalence and test characteristics derived from the three-test, random effects model, by using the international TSPOT cut-off among specified groups

ParameterForeign-born, HIV-seronegative, aged ≥5 years, % (95% credible interval)Foreign-born, HIV-seronegative, aged <5 years, % (95% credible interval)Foreign-born, HIV-seropositive, aged ≥5 years, % (95% credible interval)US-born, HIV-seronegative, aged ≥5 years, % (95% credible interval)US-born, HIV-seropositive, aged ≥5 years, % (95% credible interval)
 LTBI prevalence34.0 (27.6 to 39.2)4.0 (1.9 to 6.7)31.7 (1.9 to 46.8)17.5% (13.1 to 22.5)4.2 (2.6 to 6.3)
TST
 Sensitivity80.7 (72.6 to 90.5)69.1 (58.5 to 79.7)57.0 (49.6 to 65.3)72.6 (62.2 to 84.3)54.0 (44.2 to 64.3)
 Specificity70.0 (68.3 to 71.5)73.9 (69.6 to 77.9)88.5 (70.7 to 96.0)92.1 (89.7 to 94.3)96.5% (95.3 to 97.6)
 PPV57.9 (52.8 to 61.3)10.0 (4.8 to 16.5)69.2 (3.7 to 90.3)66.0 (56.5 to 75.4)40.4% (27.0 to 55.1)
 NPV87.3 (79.9 to 95.0)98.3 (96.7 to 99.3)81.3 (69.1 to 98.9)93.9 (89.9 to 97.3)97.9 (96.6 to 98.9)
QFT-IT
 Sensitivity78.9 (69.6 to 90.2)71.2 (55.3 to 86.5)59.1 (47.1 to72.0)78.0 (65.0 to 91.0)67.5 (52.9 to 81.7)
 Specificity98.5 (96.1 to 99.8)98.9 (97.4 to 99.9)93.1 (73.9 to 99.1)97.9 (96.0 to 99.4)95.8 (94.4 to 97.1)
 PPV96.4 (90.0 to 99.5)73.1 (41.3 to 95.3)79.0 (3.9 to 97.7)88.6 (78.6 to 97.0)41.4 (27.3 to 56.8)
 NPV89.9 (83.6 to 96.3)98.8 (97.4 to 99.6)82.8 (70.1 to 98.9)95.3 (91.1 to 98.5)98.5 (97.2 to 99.4)
TSPOT
 Sensitivity73.5 (63.9 to 86.3)58.9 (42.7 to 76.2)45.8 (35.2 to 58.6)68.5 (55.7 to 83.4)55.0 (40.7 to 70.6)
 Specificity99.3 (98.0 to 99.9)99.4 (98.4 to 99.9)97.2 (84.1 to 99.7)99.1 (98.1 to 99.8)99.3 (98.6 to 99.8)
 PPV98.2 (94.2 to 99.8)79.2 (52.0 to 96.3)86.9 (5.8 to 99.0)94.3 (87.2 to 98.9)77.5 (58.0 to 93.5)
 NPV87.7 (81.1 to 94.9)98.3 (96.5 to 99.4)79.1 (65.3 to 98.9)93.5 (89.0 to 97.3)98.0 (96.5 to 99.1)
  • Parameter values are mean estimates with 95% credible intervals in parentheses.

  • LTBI, latent TB infection; NPV, negative predictive value; PPV, positive predictive value; QFT-IT, QuantiFERON Gold In-Tube; TSPOT, T-SPOT.TB; TST, tuberculin skin test.