Table 1

Frequency of nodule characteristics stratified by lung cancer diagnosis and size

Lung cancerProportion of nodules with characteristic being lung cancer
Overall,
100% (n=1280)
No,
94% (n=1207)
Yes,
6% (n=73)
P values<30 mm3,
33% (n=429)
30–<200 mm3,
43% (n=547)
≥200 mm3,
24% (n=304)
Nodule volume0.5 (2/429)3 (18/547)17 (53/304)
 <30 mm3 34 (429/1280)35 (427/1207)3 (2/73)<0.0001
 30–<200 mm3 43 (547/1280)44 (529/1207)25 (18/73)0.001
 ≥200 mm3 24 (304/1280)21 (251/1207)73 (53/73)<0.0001
 Median (mm3) (IQR)50 (23–156)47 (22–132)387 (124–1017)<0.0001
Location
 Right upper lung26 (327/1277)25 (299/1204)38 (28/73)0.0132 (2/100)5 (7/155)26 (19/72)
 Left upper lung21 (273/1277)22 (259/1204)19 (14/73)0.7690 (0/94)4 (5/122)16 (9/57)
 Right lower lung33 (424/1277)34 (207/1204)23 (17/73)0.0730 (0/143)1 (2/166)13 (15/115)
 Left lower lung20 (253/1277)20 (239/1204)19 (14/73)1.0000 (0/92)4 (4/103)17 (10/58)
Right or left lung
 Right lung59 (751/1277)59 (706/1204)62 (45/73)0.7141 (2/243)3 (9/321)18 (34/187)
 Left lung41 (526/1277)41 (498/1204)38 (28/73)0.7140 (0/186)4 (9/225)17 (19/115)
Distribution
 Central22 (281/1272)21 (255/1199)36 (26/73)0.0080 (0/87)6 (8/134)30 (18/60)
 Peripheral78 (991/1272)79 (944/1199)64 (47/73)0.0081 (2/341)2 (10/410)15 (35/240)
Shape
 Round56 (638/1137)57 (613/1076)41 (25/61)0.0170.3 (1/311)2 (4/255)28 (20/72)
 Polygonal35 (400/1137)35 (378/1076)36 (22/61)0.8911 (1/94)4 (8/204)13 (13/102)
 Irregular9 (99/1137)8 (85/1076)23 (14/61)0.00040 (0/2)5 (1/20)17 (13/77)
Margin
 Smooth53 (671/1260)55 (656/1189)21 (15/71)<0.00010.3 (1/390)3 (7/244)19 (7/37)
 Lobulated36 (453/1260)35 (417/1189)51 (36/71)0.0100 (0/32)4 (10/272)17 (26/149)
 Spiculated7 (82/1260)6 (68/1189)20 (14/71)<0.00010 (0/2)0 (0/12)21 (14/68)
 Irregular4 (54/1260)4 (48/1189)9 (6/71)0.11933 (1/3)0 (0/12)13 (5/39)
Visibility in retrospect
 Not visible80 (1025/1280)80 (960/1207)89 (65/73)0.0500 (0/201)3 (14/528)17 (51/296)
 Small nodule <15 mm3 20 (255/1280)20 (247/1207)11 (8/73)0.0501 (2/228)21 (4/19)25 (2/8)
  • Missing values were excluded from analyses.