The association of baseline characteristics with urate tertiles, COPD and the combined allele score in the Copenhagen General Population Study (CGPS)
| Urate tertiles | P for trend | COPD | P | Allele score P for trend | ||||
| First | Second | Third | No | Yes | ||||
| No. of individuals | 38 394 | 34 427 | 32 379 | n=105 200 | 86 009 | 12 957 | n=98 966 | n=100 540 |
| Plasma urate (µmol/L) | 230 (200–280) | 290 (260–350) | 390 (330–430) | 300 (240–360) | 300 (250–370) | 6×10−25 | <1×10−300 | |
| Men, n (%) | 17 089 (45) | 15 678 (46) | 14 599 (45) | 0.33 | 38 475 (45) | 6418 (50) | 2×10−24 | 0.83 |
| Age (years) | 55 (46–65) | 58 (48–67) | 62 (52–70) | <1×10−300 | 57 (48–67) | 63 (53–71) | <1×10−300 | 0.41 |
| Ever-smokers, n (%) | 21 352 (56) | 19 956 (58) | 20 111 (62) | 2×10−68 | 47 932 (56) | 9780 (75) | <1×10−300 | 0.43 |
| Cumulative tobacco consumption (pack-years) | 14 (5–27) | 15 (6–29) | 19 (8–34) | 7×10−168 | 14 (5–27) | 25 (13–40) | <1×10−300 | 0.97 |
| Body mass index (kg/m2) | 24 (22–27) | 26 (23–28) | 27 (25–30) | <1×10−300 | 26 (23–28) | 25 (23–28) | 4×10−63 | 0.14 |
| Alcohol consumption (g/week) | 85 (36–168) | 96 (48–180) | 108 (48–192) | 4×10−133 | 96 (48–180) | 108 (48–204) | 2×10−29 | 0.68 |
| High income, n (%) | 18 534 (48) | 15 410 (45) | 11 444 (35) | 4×10−258 | 38 449 (45) | 4417 (34) | 2×10−114 | 0.41 |
| High physical activity in leisure time, n (%) | 2907 (8) | 2385 (7) | 1775 (6) | 3×10−28 | 5811 (7) | 810 (6) | 0.03 | 0.67 |
| High education, n (%) | 19 278 (50) | 16 126 (47) | 12 512 (39) | 8×10−205 | 39 885 (46) | 5258 (41) | 5×10−35 | 0.41 |
| Exposure to occupational dust and fumes, n (%) | 3312 (9) | 3325 (10) | 3890 (12) | 5×10−50 | 7881 (9) | 1681 (13) | 1×10−42 | 0.02 |
| High intake of meat, n (%) | 4297 (11) | 3950 (11) | 3933 (12) | 3×10−32 | 9834 (11) | 1588 (12) | 3×10−5 | 0.92 |
| Pre-existing cardiovascular disease, n (%) | 1628 (4) | 1775 (5) | 2788 (9) | 1×10−129 | 4672 (5) | 1060 (8) | 9×10−36 | 0.71 |
| Creatinine (µmol/L) | 77 (69–85) | 80 (72–89) | 84 (75–94) | <1×10−300 | 80 (72–89) | 79 (71–89) | 8×10−8 | 0.41 |
| C-reactive protein (mg/L) | 1.2 (0.76–1.8) | 1.4 (0.93–2.2) | 1.7 (1.2–3.1) | <1×10−300 | 1.4 (0.92–2.2) | 1.5 (0.95–2.6) | 2×10−31 | 0.94 |
Continuous variables are shown as median and IQR. Urate tertiles were assigned by sex. COPD was defined as lower limit of normal. Allele score: urate SLC2A9 rs7442295 variant+urate ABCG2 rs2331142 variant. Individuals with self-reported asthma (n=6234 in the CGPS) are excluded from COPD analyses. P for trend was calculated using Cuzick’s non-parametric test for trend.