Table 6

Clinical exclusion criteria for outpatient PE management

Hestia criteria (Zondag et al)³⁰	Davies et al⁷
Is the patient haemodynamically unstable?*	Yes/no	Need for hospitalisation for another medical reason	Yes/no
Is thrombolysis or embolectomy necessary?	Yes/no	Additional monitoring required (ECG, oxygen, parenteral analgesia)	Yes/no
Active bleeding or high risk of bleeding?†	Yes/no	Likelihood of poor compliance/difficulty with follow-up	Yes/no
More than 24 hours of oxygen supply to maintain oxygen saturation >90%?	Yes/no	Previous PE/early recurrence of PE	Yes/no
Is PE diagnosed during anticoagulant treatment?	Yes/no	Coexisting major DVT	Yes/no
Severe pain needing intravenous pain medication for >24 hours?	Yes/no	Bleeding disorders, active bleeding	Yes/no
Medical or social reason for treatment in hospital >24 hours?	Yes/no	Pregnancy	Yes/no
Does the patient have a creatinine clearance <30 mL/min?	Yes/no	Patient preference for hospital stay	Yes/no
Does the patient have severe liver impairment? (discretion of clinician)	Yes/no
Is the patient pregnant?	Yes/no
Does the patient have a documented history of heparin-induced thrombocytopenia ?	Yes/no
Eligible for outpatient treatment—no risk factors. Ineligible for outpatient treatment—at least one risk factor present.

*SBP <100 mm Hg with HR >100 bpm; condition requiring admission to intensive care unit.
†Gastrointestinal bleeding in the preceding 14 days, recent stroke (<4 weeks ago), recent operation (<2 weeks ago), bleeding disorder, thrombocytopenia (platelet count <75 x 10⁹/l), uncontrolled hypertension (SBP >180 mm Hg or DBP >110 mm Hg).
DVT, deep vein thrombosis; DBP, diastolic blood pressure; SBP, systolic blood pressure.