Baseline sleep and cardiometabolic parameters of the ITT population
| Variables | ERGO (n=18) | ERGO+RMT (n=18) | ERGO+NIV (n=17) |
| Mean CPAP use (hour) | 6.7 (6.0; 7.7) | 7.5 (6.4; 8.1) | 6.7 (6.0; 7.4) |
| AHI (events/hour of sleep) | 2.8 (2.4; 3.3) | 2.2 (1.8; 3.6) | 2.3 (1.8; 2.6) |
| Mean nocturnal SpO2 (%) | 95.3 (94.0; 96.5) | 95.9 (94.8; 96.5) | 95.0 (93.5; 95.5) |
| Epworth sleepiness score | 8.0 (6.0; 10.5) | 7.5 (5.5; 11.0) | 7.5 (5.5; 9.0) |
| Self-measured blood pressure | |||
| Systolic BP (mm Hg) | 130. (125.0; 134.5) | 130.5 (121.5; 134.0) | 135.0 (126.5; 143.5) |
| Diastolic BP (mm Hg) | 76.5 (74.0; 83.0) | 78.8 (66.5; 85.5) | 82.0 (77.5; 85.5) |
| Heart rate (beat/min) | 65.5 (58.5; 71.5) | 66.5 (60.0; 71.5) | 68.0 (66.0; 75.0) |
| PWV (m/s) | 9.5 (8.2; 10.8) | 9.5 (9.2; 10.1) | 10.9 (9.1; 12.4) |
| RH-PAT | 0.6 (0.4; 0.7) | 0.5 (0.4; 0.8) | 0.5 (0.3; 0.6) |
| Metabolic and inflammatory biomarkers | |||
| Total cholesterol (g/L) | 1.9 (1.4; 2.1) | 1.7 (1.6; 2.1) | 2.0 (1.7; 2.1) |
| LDL/HDL cholesterol ratio | 3.8 (3.5; 4.5) | 4.2 (3.5; 5.3) | 4.4 (3.9; 5.0) |
| Triglycerides (g/L) | 1.4 (1.2; 1.9) | 1.4 (1.1; 1.7) | 1.4 (1.0; 1.7) |
| Glucose (mmol/L) | 5.4 (5.1; 6.6) | 6.1 (5.5; 8.1) | 5.7 (5.5; 6.4) |
| Insulin (µUI/mL) | 17.5 (13.7; 24.4) | 20.4 (15.2; 29.3) | 17.7 (9.7; 27.5) |
| HOMA index | 4.1 (3.2; 9.8) | 5.3 (3.7; 10.4) | 4.5 (2.5; 6.9) |
| Free fatty acids (mmol/L) | 63 (426; 702) | 495 (417; 626) | 488 (421; 605) |
| hsCRP (mg/L) | 3.4 (2.1; 6.7) | 3.9 (2.5; 8.5) | 3.2 (2.0; 4.0) |
Data are median (IQR) or number (%).
AHI, apnoea hypopnea index; CPAP, continuous positive airway pressure; DBP, diastolic blood pressure; ERGO, ergocycle training; HOMA, homeostasis model assessment=insulinaemia (mU/L)×glycaemia (mmol/L)/22.5; HR, heart rate; hsCRP, high sensitive C-reactive protein; ITT, intention to treat; LDL/HDL, low density lipid to high density lipids ratio; NIV, non-invasive ventilation; PWV, pulse wave velocity; RH-PAT, reactive hyperaemia peripheral arterial tonometry; RMT, respiratory muscle training; SaO2, oxygen saturation; SBP, systolic blood pressure; 6MWD, 6 min walking distance.