Table 3

Changes after training in 6MWD, aerobic capacity and muscle strength in the three intervention groups (ITT analysis)

ERGOERGO+RMTERGO+NIVP value
Outcomes (change in ITT analysis)
 6MWT
   Distance (m)26 (33)23 (52)25 (27)0.97
   End dyspnoea (VAS 0–10)−0.5 (2.6)−1.4 (1.8)−0.4 (1.6)0.32
   End leg fatigue (VAS 0–10)−1.1 (2.9)−1.1 (2.3)−0.1 (1.6)0.31
  Incremental exercise capacity
    Peak workload (W)20 (28)31 (29)24 (22)0.44
    Peak HR (beat/min)−2.0 (13.6)4.4 (15.4)0.7 (11.5)0.37
    Peak VO2 (mL/min/kg)0.49 (3.65)2.28 (3.04)*3.11 (2.27)*0.04
    Peak VE (L/min)1.8 (14.1)17.5 (11.9)*1.9 (17.2)0.002
    Peak IC (L)0.1 (0.4)0.4 (0.7)0.1 (0.5)0.19
    Peak dyspnoea score0.0 (1.9)0.8 (2.2)−0.8 (2.9)0.09
    Peak leg fatigue score0.4 (3.0)0.4 (1.8)0.0 (2.0)0.85
  Quadriceps MVC (kg)−4.6 (20.9)1.0 (8.1)2.3 (1.2)0.62
  Quadriceps endurance (s)−5.2 (13.6)−2.8 (22.0)1.1 (9.6)0.81
  Inspiratory muscle strength (mm H2O)−1.2 (31.3)16.5 (27.4)13.0 (30.9)0.18
  Expiratory muscle strength (mm H2O)22.5 (33.4)−5.8 (57.2)−13.8 (58.2)0.09
  SF-36 physical domain5.7 (7.2)6.8 (8.7)2.1 (4.7)0·10
  SF-36 mental domain1.7 (6.9)7.8 (8.3)3.2 (8·6)0·06
Training parameters (change in adherents only)
  Workload (W)31 (22)40 (23)27 (26)0.15
  Duration (min)15 (3)12 (5)14 (4)0.05
  Dyspnoea (VAS 0–10)0.8 (1.8)−0.5 (2.6)−1.1 (2.4)0.06
  Leg fatigue (VAS 0–10)0.7 (2.2)−0.3 (3.2)−0.3 (2.4)0.47
  • Data are mean (SD).

  • *Significant post hoc test with Bonferroni correction (significance at P=0.0083).

  • ERGO, ergocycle training; HR, heart rate; IC, inspiratory capacity; ITT, intention to treat; MVC, maximal voluntary contraction; NIV, non-invasive ventilation; RMT, respiratory muscle training; VAS, visual analogue scale; VE, minute ventilation; VO2, oxygen uptake; 6MWT, 6 min walking test.