Genes downregulated with age in COPD | Genes upregulated with age in COPD | ||
Name | FDR | Name | FDR |
KIAA1462 | 0.036 | Deoxyribonuclease I-like 3 (DNASE1L3) | 0.036 |
G protein-coupled receptor 173 (GPR173) | 0.036 | Retinol binding protein 5 (RBP5) | 0.036 |
Major facilitator superfamily domain containing 4 (MFSD4) | 0.117 | Myosin VIIA and Rab interacting protein (MYRIP) | 0.117 |
Peptidylglycine alpha-amidating monooxygenase (PAM) | 0.177 | Finkel-Biskis-Reilly murine sarcoma virus (FAU) | 0.127 |
Solute carrier family 8 member 2 (SLC8A2) | 0.188 | Erythrocyte membrane protein band 4.1 like 4A (EPB41L4A) | 0.177 |
Inter-alpha-trypsin inhibitor heavy chain family member 5 (ITIH5) | 0.188 | Glioma tumour suppressor candidate region gene 2 (GLTSCR2) | 0.192 |
CD38 molecule (CD38) | 0.188 | FAM91a2 (FAM91A2) | 0.192 |
Visinin like 1 (VSNL1) | 0.188 | Haem oxygenase 2 (HMOX2) | 0.192 |
Intraflagellar transport 57 (IFT57) | 0.192 | Synaptojanin 2 (SYNJ2) | 0.192 |
Beta-1,3-N-acetylgalactosami-nyltransferase 1 (B3GALNT1) | 0.192 | Sp1 transcription factor (SP1) | 0.193 |
Anterior gradient 3 (AGR3) | 0.192 | Neuron navigator 2 (NAV2) | 0.193 |
Nipsnap homologue 3A (NIPSNAP3A) | 0.192 | Septin 6 (SEPT6) | 0.201 |
Collagen, type VI, alpha 3 (COL6A3) | 0.200 | Myeloid/lymphoid or mixed-lineage leukaemia; translocated to, 6 (MLLT6) | 0.201 |
RAB2A, member RAS oncogene family (RAB2A) | 0.201 | C18orf34 | 0.201 |
Collagen, type III, alpha 1 (COL3A1) | 0.201 | MYC-associated zinc finger protein (MAZ) | 0.201 |
Coagulation factor VIII (F8) | 0.201 | Ribosomal protein L38 (RPL38) | 0.201 |
Solute carrier family 9, subfamily A, member 9 (SLC9A9) | 0.201 | Zinc finger protein 212 (ZNF212) | 0.201 |
Neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) | 0.201 | ATP binding cassette subfamily G member 2 (ABCG2) | 0.201 |
Fucosyltransferase 8 (FUT8) | 0.224 | Phosphoglucomutase 5 pseudogene 1 (PGM5P1) | 0.204 |
Leucocyte cell derived chemotaxin 1 (LECT1) | 0.224 | Rap guanine nucleotide exchange factor 1 (RAPGEF1) | 0.206 |
GRINL1A complex locus 1 (GCOM1) | 0.232 | Sodium channel, voltage gated, type III beta subunit (SCN3B) | 0.224 |
Tumour suppressor candidate 3 (TUSC3) | 0.232 | Protein tyrosine phosphatase, receptor type, R (PTPRR) | 0.224 |
Sema domain 3C (SEMA3C) | 0.242 | Glucocorticoid modulatory element binding protein 2 (GMEB2) | 0.224 |
Ribophorin I (RPN1) | 0.246 | Abhydrolase domain containing 6 (ABHD6) | 0.224 |
MRE11 homologue A (MRE11A) | 0.246 | Eukaryotic elongation factor two kinase (EEF2K) | 0.224 |
Mutated in colorectal cancers (MCC) | 0.246 | UBX domain protein 1 (UBXN1) | 0.232 |
Transmembrane protein 63B (TMEM63B) | 0.246 | Erythrocyte membrane protein band 4.1 (EPB41) | 0.238 |
Collagen, type IV, alpha 1 (COL4A1) | 0.246 | Interleukin four receptor (IL4R) | 0.238 |
Solute carrier family 44, member 1 (SLC44A1) | 0.246 | Calbindin 1 (CALB1) | 0.245 |
Coiled-coil domain containing 53 (CCDC53) | 0.248 | Zinc finger protein 764 (ZNF764) | 0.246 |
Leukotriene B4 receptor (LTB4R) | 0.246 | ||
Nuclear fragile X mental retardation protein interacting protein 2 (NUFIP2) | 0.246 | ||
Transcription factor-like 5 (TCFL5) | 0.246 | ||
C7orf20 | 0.246 | ||
Fibrillarin (FBL) | 0.246 | ||
hCG (hCG33730) | 0.246 | ||
Oxidase (cytochrome c) assembly 1-like (OXA1L) | 0.246 | ||
Nuclear factor I/C (NFIC) | 0.246 | ||
Sad1 and UNC84 domain containing 2 (UNC84B) | 0.248 |