Cox hazard ratios (HR) for incident acute coronary syndrome, transient ischaemic attack, stroke or death for OSA clusters (n=1036*)
| Variables | Unadjusted | Adjusted by CPAP use | ||||
| Cluster label | HR | 95% CI | p Value | HR | 95% CI | p Value |
| Mild | Ref | – | 0.0002 | Ref | – | <0.0001 |
| PLMS | 2.36 | 1.61 to 3.46 | 2.48 | 1.69 to 3.64 | ||
| NREM and poor sleep | 1.66 | 1.15 to 2.40 | 1.74 | 1.20 to 2.51 | ||
| REM and hypoxia | 1.34 | 0.91 to 1.99 | 1.45 | 0.98 to 2.16 | ||
| Hypopnoea and hypoxia | 1.69 | 1.04 to 2.77 | 1.92 | 1.17 to 3.15 | ||
| Arousal and poor sleep | 2.33 | 1.32 to 4.10 | 2.42 | 1.37 to 4.26 | ||
| Combined severe | 1.78 | 1.19 to 2.66 | 1.91 | 1.27 to 2.85 | ||
| CPAP use | – | 0.0015 | ||||
| Not regular | – | – | Ref | |||
| Regular | – | – | 0.64 | 0.49 to 0.84 | ||
*Subjects without any component of the Framingham risk score excluded.
AHI, apnoea–hypopnoea index (events per hour); BMI, body mass index; CCI, Charlson comorbidity index; CPAP, continuous positive airway pressure; ESS, Epworth sleepiness scale; FRS, Framingham risk score; OSA, obstructive sleep apnoea; PLMS, periodic limb movements of sleep; NREM, non-rapid eye movement; REM, rapid eye movement.