Table 5

Cox hazard ratios (HR) for incident acute coronary syndrome, transient ischaemic attack, stroke or death for OSA clusters (n=1036*)

VariablesUnadjustedAdjusted by CPAP use
Cluster labelHR95% CIp ValueHR95% CIp Value
PLMS2.361.61 to 3.462.481.69 to 3.64
NREM and poor sleep1.661.15 to 2.401.741.20 to 2.51
REM and hypoxia1.340.91 to 1.991.450.98 to 2.16
Hypopnoea and hypoxia1.691.04 to 2.771.921.17 to 3.15
Arousal and poor sleep2.331.32 to 4.102.421.37 to 4.26
Combined severe1.781.19 to 2.661.911.27 to 2.85
CPAP use 0.0015
Not regularRef
Regular0.640.49 to 0.84
  • *Subjects without any component of the Framingham risk score excluded.

  • AHI, apnoea–hypopnoea index (events per hour); BMI, body mass index; CCI, Charlson comorbidity index; CPAP, continuous positive airway pressure; ESS, Epworth sleepiness scale; FRS, Framingham risk score; OSA, obstructive sleep apnoea; PLMS, periodic limb movements of sleep; NREM, non-rapid eye movement; REM, rapid eye movement.