Main clinical, physiological and HRCT characteristics in patients separated according to <10% (n=77) and ≥10% predicted FVC (n=35) after 6–12-month period
Finding | <10% FVC (n=77) | ≥10% FVC (n=35) | p Value |
Age, years | 57.3±13.0 | 61.1±13.7 | 0.16 |
Female sex, n (%) | 55 (71.4) | 23 (74.3) | 0.37 |
Weight loss, n (%) | 26 (33.8) | 9 (25.7) | 0.88 |
Dyspnoea, n (%) | 69 (89.6) | 29 (82.9) | 0.32 |
Fine crackles, n (%) | 61 (79.2) | 29 (82.9) | 0.65 |
Clubbing, n (%) | 10 (13.0) | 11 (31.4) | 0.55 |
Inspiratory squeaks, n (%) | 11 (14.3) | 4 (11.4) | 0.68 |
FVC % predicted, mean ± SD | 66.1±18.6 | 72.6±17.9 | 0.09 |
FEV1/FVC | 0.86±0.07 | 0.86±0.08 | 0.89 |
SpO2, rest, mean ± SD (n=103) | 93.9±4.2 | 92.9±4.4 | 0.28 |
Reticular pattern, n (%) | 51 (66) | 24 (68) | 0.71 |
Ground-glass opacities, n (%) | 41 (53) | 22 (62) | 0.34 |
Mosaic, n (%) | 34 (44) | 16 (45) | 0.87 |
Honeycombing, n (%) | 26 (33) | 10 (28) | 0.58 |
Centrilobular nodules, n (%) | 17 (22) | 6 (17) | 0.54 |
Vertical distribution—diffuse/upper lobes/lower lobes, n | 21/22/33 | 9/10/14 | 0.99 |
Axial distribution—central, peripheral, both, n | 9/23/44 | 9/9/21 | 0.62 |