Table 3

List of demographic and baseline clinical variables significantly associated with temporal variability of microbial alpha and beta diversity among subjects

Temporal variability	Alpha diversity (Shannon)				Beta diversity (weighted UniFrac distance)
Temporal variability	All	London	Leicester	Manchester	All	London	Leicester	Manchester
Historical number of exacerbations per year	0.01*	0.01*	3e–4*	0.32	0.01*	0.03*	0.47	0.21
BMI	0.11†	0.73	0.01*	0.53	0.51	0.70	0.04*	0.88
CES-D score	0.50	0.03	0.35	0.68	0.44	0.32	0.63	0.01*
Packs of cigarette per year	0.40	0.67	0.31	0.38	0.07†	0.50	0.02*	0.58
FEV₁	0.03	0.76	0.59	0.82	0.64	0.95	0.17†	0.41
FEV₁/FVC ratio	0.65	0.88	0.01*	0.40	0.87	0.36	0.77	0.98
Age	0.54	0.03*	0.38	0.23	0.70	0.37	0.99	0.26
SGRQ total score	0.61	0.92	0.80	0.38	0.33	0.44	0.40	0.03*
Centre	2.6e–12*	NA	NA	NA	1.8e–10*	NA	NA	NA

P values are indicated for variables in the model.
*Significant variables.
†Variables not statistically significant but present in the model.
BMI, body mass index; FEV₁, forced expiratory volume in one second; FVC, forced vital capacity.