Table 3

List of demographic and baseline clinical variables significantly associated with temporal variability of microbial alpha and beta diversity among subjects

Temporal variabilityAlpha diversity (Shannon)Beta diversity (weighted UniFrac distance)
Historical number of exacerbations per year0.01*0.01*3e–4*0.320.01*0.03*0.470.21
CES-D score0.500.030.350.680.440.320.630.01*
Packs of cigarette per year0.400.670.310.380.07†0.500.02*0.58
FEV1 0.030.760.590.820.640.950.17†0.41
FEV1/FVC ratio0.650.880.01*0.400.870.360.770.98
SGRQ total score0.610.920.800.380.330.440.400.03*
  • P values are indicated for variables in the model.

  • *Significant variables.

  • †Variables not statistically significant but present in the model.

  • BMI, body mass index; FEV1, forced expiratory volume in one second; FVC, forced vital capacity.