Diagnostic performance of pleural IL-27, ADA and IFN-γ in in differentiating between patients with tuberculous pleural effusion (TPE) and those with non-TPE in the Wuhan cohort (n=120)
| Variable | AUC (95% CI) | Sensitivity (%) | Specificity (%) | PLR | NLR | PPV | NPV |
| IL-27,>591.4 ng/L | 0.982* (0.939 to 0.998) | 97.7 (88.0 to 99.9) | 98.7 (92.9 to 100.0) | 74.3 (10.6 to 520.8) | 0 (0 to 0.2) | 97.7 (88.0 to 99.9) | 98.7 (92.9 to 100.0) |
| ADA,>21.4 U/L | 0.877 (0.805 to 0.930) | 88.6 (75.4 to 96.2) | 86.8 (77.1 to 93.5) | 6.7 (3.7 to 12.1) | 0.1 (0.1 to 0.3) | 79.6 (65.5 to 89.8) | 93.0 (84.3 to 97.7) |
| IFN-γ,>116.1 ng/L | 0.953† (0.898 to 0.983) | 93.2 (81.3 to 98.6) | 97.4 (90.8 to 99.7) | 35.4 (9.0 to 139.3) | 0.1 (0 to 0.2) | 95.3 (84.0 to 99.5) | 96.1 (89.0 to 99.2) |
| IL-27•ADA, >14 4960.8 ng U/L2 | 0.943‡ (0.885 to 0.977) | 88.6 (75.4 to 96.2) | 100.0 (95.3 to 100.0) | ‒ | 0.1 (0.1 to 0.3) | 100.0 (90.7 to 100.0) | 93.8 (86.2 to 98.0) |
*p = 0.006, †p=0.032, 0 p=0.010, compared with ADA using the z statistic, respectively.
ADA, adenosine deaminase; AUC, area under the curve; IL-27, interleukin 27; IFN-γ, interferon-γ; IL-27•ADA, the product of IL-27 and ADA; NLR, negative likelihood ratio; NPV, negative predictive value; PLR, positive likelihood ratio; PPV, positive predictive value.