Diagnostic performance of pleural IL-27, ADA and IFN-γ in differentiating between patients with tuberculous pleural effusion (TPE) and those with non-TPE in the Beijing cohort (n=154)
| Variable | Cut-off value | AUC (95% CI) | Sensitivity (%) | Specificity (%) | PLR | NLR | PPV | NPV |
| IL-27 | 591.4 ng/L | 0.983* (0.947 to 0.997) | 96.1 (86.5 to 99.5) | 99.0 (94.7 to 100.0) | 99.0 (14.1 to 696.4) | 0 (0 to 0.2) | 98.0 (89.4 to 99.9) | 98.1 (93.3 to 99.8) |
| ADA | 21.4 U/L | 0.900 (0.842 to 0.943) | 88.2 (76.1 to 95.6) | 86.4 (78.2 to 92.4) | 6.5 (3.9 to 10.7) | 0.1 (0.1 to 0.3) | 76.3 (63.4 to 86.4) | 93.7 (86.7 to 97.7) |
| IFN-γ | 116.1 ng/L | 0.973† (0.933 to 0.992) | 92.2 (81.1 to 97.8) | 95.2 (89.0 to 98.4) | 19.0 (8.0 to 44.8) | 0.1 (0 to 0.2) | 90.4 (79.0 to 96.8) | 96.1 (90.3 to 98.9) |
| IL-27•ADA | 14 496.8 ng U/L2 | 0.979‡ (0.943 to 0.995) | 90.2 (78.6 to 96.7) | 100.0 (96.5 to 100.0) | ‒ | 0.1 (0 to 0.2) | 100.0 (92.3 to 100.0) | 95.4 (89.5 to 98.5) |
*p = 0.012, †p=0.022, ‡p<0.001, compared with ADA using the z statistic, respectively.
ADA, adenosine deaminase; AUC, area under the curve; IL-27, interleukin 27; IFN-γ, interferon-γ; IL-27•ADA, product of IL-27 and ADA; NLR, negative likelihood ratio; NPV, negative predictive value; PLR, positive likelihood rati0; PPV, positive predictive value.