Table 10

Summary of immunohistochemistry markers

Marker	Immunoreactivity for mesothelioma	Specimen	Sensitivity (%)	Specificity (%)
Calretinin	Positive staining	Histological	89–100^186–201	61–95^186–201
Thrombomodulin	Positive staining	Histological	52–100^{186–188 190–192 194 198 202–210}	56–98^{186–188 190–192 194 198 202–210}
		Cytological	67–86^{206 207}	36–47.5^{206 207}
CK5/6	Positive staining	Histological	89–100^{186–189 191 194 211}	58–97^{186–189 191 194 211}
MOC31	Negative staining	Histological	89–94^{186 189 195 212}	86–90^{186 189 195 212}
		Cytological	88²¹³	76²¹³
BerEp4	Negative staining	Histological	84–97^{186 190 191 195 196 205 208 212 214}	65–100^{186 190 191 195 196 205 208 212 214}
		Cytological	71–84 ^{206 213 215 216}	83–100 ^{206 213 215 216}
CEA	Negative staining	Histological	90–100^{186 187 190–192 195–197 203 205 212 214 217 218}	53–97^{186 187 190–192 195–197 203 205 212 214 217 218}
		Cytological	71–100^{206 213 215 216}	42–100^{206 213 215 216}
TTF-1	Negative staining	Histological	93–100^{187 191 195 197 219 220}	53–77^{187 191 195 197 219 220}
CAM 5.2	Positive staining	Histological	97–100^{187 195 196 200 205 214}	0–1.5^{187 195 196 200 205 214}
EMA	Positive staining (cell membrane)	Histological	74.5–90^{187 190 191 193 195 205 214 221}	7–87^{187 190 191 193 195 205 214 221}
		Cytological	58–78 ^{206 215 216}	8–99 ^{206 215 216}
Leu-M1	Negative staining	Histological	94–100^{196 203 214}	53–77^{196 203 214}
		Cytological	86^{213 215}	65^{213 215}
Vimentin	Positive staining	Histological	60–85^{190 203 205 214 217}	64–98^{190 203 205 214 217}
		Cytological	79–84 ^{206 215}	38–50^{206 215}
HBME-1	Positive staining	Histological	59–100^{187 190 192 196 202 205 208 210 212 222}	28–76^{187 190 192 196 202 205 208 210 212 222}
		Cytological	71–89 ^{206 207}	36–52 ^{206 207}
WT-1	Positive staining	Histological	72–91^{187–189 195 223}	88–100^{187–189 195 223}
CD15	Negative staining	Histological	68–95^{187 189–192 205}	73–100^{187 189–192 205}
B72.3	Negative staining	Histological	90–100^{187 191 203 208 212 214}	4.2–90^{187 191 203 208 212 214}
BG8	Negative staining	Histological	83–94^{187 223}	88.5–98^{187 223}
Desmin	Positive staining	Histological	45–90^{214 221}	85–100^{214 221}
p53	Positive staining	Histological	45–95^{193 221 224}	47–100^{193 221 224}
GLUT-1	Positive staining	Histological	58–100^{225 226}	100^{225 226}
CD90	Positive staining	Histological	73²²⁷	82²²⁷
Claudin-4	Negative staining	Histological	100²²⁸	99²²⁸
D-240	Positive staining	Histological	72.5²²⁹	93.5²²⁹