Data on morphometry, autofluorescence intensity, CT density and their variability
| Healthy | Emphysema | Significance | |
|---|---|---|---|
| Median values per group | |||
| LDAD in µm (IQR) | |||
| Total | 297 (244–357) | 327 (261–401) | p=0.01 |
| Lower lobe | 289 (239–328) | 315 (251–382) | p=0.03 |
| Upper lobe | 359 (331–421) | 376 (290–451) | p=0.3 |
| ADA in 104 µm2 (IQR) | |||
| Total | 5.2 (3.9–7.1) | 7.2 (4.4–11.4) | p=0.0002 |
| Lower lobe | 4.9 (3.8–6.9) | 7.0 (4.0–11.4) | p=0.002 |
| Upper lobe | 6.7 (4.1–7.5) | 8.6 (6.0–11.7) | p=0.04 |
| EFT in µm (IQR) | |||
| Total | 6.3 (5.2–7.7) | 6.4 (5.5–7.7) | p=0.2 |
| Lower lobe | 6.3 (4.9–7.7) | 6.4 (5.4–7.7) | p=0.01 |
| Upper lobe | 6.2 (5.4–6.8) | 6.4 (5.6–7.6) | p=0.2 |
| Mean IQR per measurement | |||
| IQR LDAD in µm (95% CI) | |||
| Total | 97 (66 to 135) | 135 (113 to 157) | p=0.07 |
| Lower lobe | 109 (61 to 156) | 131 (106 to 156) | p=0.3 |
| Upper lobe | 115 (68 to 151) | 142 (117 to 168) | p=0.04 |
| IQR ADA in 104 µm2 (95% CI) | |||
| Total | 2.9 (1.9 to 3.8) | 5.1 (4.1 to 6.1) | p=0.02 |
| Lower lobe | 3.8 (2.6 to 4.8) | 4.5 (3.7 to 5.4) | p=0.001 |
| Upper lobe | 2.3 (1.4 to 8.8) | 5.5 (4.1 to 7.0) | p=0.04 |
| IQR EFT in µm (95% CI) | |||
| Total | 2.7 (2.2 to 3.2) | 2.5 (2.2 to 2.8) | p=0.8 |
| Lower lobe | 2.8 (2.2 to 3.3) | 2.6 (2.1 to 3.1) | p=0.6 |
| Upper lobe | 1.6 (1.2 to 1.9) | 2.2 (1.9 to 2.5) | p=0.03 |
| Autofluorescence intensity | |||
| mAFI (mean value (95% CI)) | |||
| Total | 101 (80 to 121) | 45 (33 to 58) | p<0.0001 |
| Lower lobe | 46 (31 to 60) | ||
| Upper lobe | 45 (31 to 58) | ||
| fAFI (mean value (95% CI)) | |||
| Total | 79 (59 to 98) | 29 (17 to 41) | p<0.0001 |
| Lower lobe | 34 (21 to 48) | ||
| Upper lobe | 37 (24 to 50) | ||
| PA100 (mean % (95% CI)) | |||
| Total | 45 (25 to 64) | 73 (55 to 91) | p=0.03 |
| Lower lobe | 71 (55 to 86) | ||
| Upper lobe | 78 (61 to 96) | ||
| CT density | Emphysema | ||
| LMD (mean value HU (95% CI)) | |||
| Total | −855 (−922 to −789) | ||
| Lower lobe | −853 (−881 to −825) | ||
| Upper lobe | −883 (−916 to −850) | ||
| 15P (mean value HU (95% CI)) | |||
| Total | −970 (−998 to −941) | ||
| Lower lobe | −969 (−991 to −947) | ||
| Upper lobe | −984 (−1011 to −957) | ||
| LAA−950 (mean % (95% CI)) | |||
| Total | 34 (20 to 48) | ||
| Lower lobe | 30 (19 to 40) | ||
| Upper lobe | 37 (26 to 48) | ||
15P, the fifteenth percentile of pixel density; ADA, cross-sectional area of alveolar duct opening; EFT, elastic fibre thickness; fAFI, the autofluorescence intensity marking the fifteenth percentile; HU, Hounsfield units; LAA−950, the proportion of low attenuation areas with density less than −950 HU; LDAD, longest diameter of the alveolar openings at the level of the alveolar ducts; LMD, lung mean density; mAFI, median autofluorescence intensity; PA100, the proportional amount of pixels characterised by an autofluorescence intensity lower than 100.