Demographics and baseline clinical characteristics of the main study population (including patients with SUEA) and the SUEA population: all ages (≥5 years) and the adult cohorts
| All patients (age ≥5 years)* | 18–64 years old | ≥65 years old | ||||
| Variable | All ages (n=3 63 558) | SUEA (n=2940) | All 18–64 years old (n=2 42 714) | SUEA (n=1900) | All ≥65 years old (n=95 189) | SUEA (n=983) |
| Female sex, n (%) | 233 210 (64.1) | 1952 (66.4) | 158 507 (65.3) | 1269 (66.8) | 61 990 (65.1) | 650 (66.1) |
| Age at index date, mean (SD) | 49.4 (20.6) | 55.8 (17.6) | 43.0 (12.8) | 47.1 (11.6) | 75.5 (7.5) | 74.9 (7.1) |
| Body mass index, n (%)† | ||||||
| Underweight | 10 152 (3.3) | 47 (1.8) | 3948 (1.9) | 18 (1.0) | 1642 (1.9) | 20 (2.2) |
| Normal | 96 309 (31.0) | 674 (25.1) | 64 852 (30.7) | 406 (23.4) | 24 984 (29.0) | 254 (27.6) |
| Overweight | 100 937 (32.4) | 828 (30.8) | 67 176 (31.8) | 489 (28.2) | 32 116 (37.3) | 333 (36.2) |
| Obese | 103 738 (33.3) | 1135 (42.3) | 75 319 (35.6) | 821 (47.3) | 27 470 (31.9) | 312 (33.9) |
| Unknown, n | 52 422 | 256 | 31 419 | 166 | 8977 | 64 |
| Smoking status, n (%)† | ||||||
| Current smoker | 64 350 (18.0) | 530 (18.3) | 56 194 (23.4) | 476 (25.3) | 6218 (6.6) | 45 (4.6) |
| Ex-smoker | 93 359 (26.2) | 899 (31.0) | 56 807 (23.7) | 523 (27.8) | 35 941 (38.2) | 376 (38.6) |
| Never smokers | 199 299 (55.8) | 1475 (50.8) | 126 664 (52.9) | 879 (46.8) | 51 906 (55.2) | 554 (56.8) |
| Unknown, n | 6550 | 36 | 3049 | 22 | 1124 | 8 |
| Charlson comorbidity index, n (%) | ||||||
| 0 | 166 280 (45.7) | 669 (22.8) | 118 122 (48.7) | 424 (22.3) | 35 111 (36.9) | 232 (23.6) |
| 1–4 | 170 791 (47.0) | 1941 (66.0) | 114 735 (47.3) | 1337 (70.4) | 43 500 (45.7) | 560 (57.0) |
| ≥5 | 26 487 (7.3) | 330 (11.2) | 9857 (4.1) | 139 (7.3) | 16 578 (17.4) | 191 (19.4) |
| Ever-recorded comorbidity, n (%) | ||||||
| Eczema | 105 659 (29.1) | 999 (34.0) | 68 507 (28.2) | 661 (34.8) | 25 188 (26.5) | 302 (30.7) |
| Allergic rhinitis | 62 490 (17.2) | 608 (20.7) | 45 790 (18.9) | 427 (22.5) | 12 789 (13.4) | 163 (16.6) |
| Non-allergic rhinitis | 32 285 (8.9) | 422 (14.4) | 19 918 (8.2) | 245 (12.9) | 10 825 (11.4) | 172 (17.5) |
| Chronic sinusitis | 35 708 (9.8) | 456 (15.5) | 24 940 (10.3) | 287 (15.1) | 10 351 (10.9) | 169 (17.2) |
| Nasal polyps | 12 949 (3.6) | 376 (12.8) | 7070 (2.9) | 218 (11.5) | 5802 (6.1) | 158 (16.1) |
| Gastro-oesophageal reflux disease | 42 154 (11.6) | 515 (17.5) | 25 129 (10.4) | 293 (15.4) | 16 323 (17.1) | 221 (22.5) |
| Cardiovascular disease | 93 443 (25.7) | 1080 (36.7) | 44 393 (18.3) | 507 (26.7) | 48 411 (50.9) | 572 (58.2) |
*All patients with SUEA included 14 children who were 5–11 years old and 43 adolescent patients 12–17 years old.
†The percentages for BMI and for smoking status were calculated for patients with available data. Overall, patients with missing data for BMI represented 14% of patients and for smoking status, 2% of patients. The BMI categories, determined from data closest to the index date, were defined as follows: underweight, <18.5 kg/m2; normal weight, ≥18.5 kg/m2 to <25 kg/m2); overweight, ≥25 kg/m2 to <30 kg/m2; and obese, ≥30 kg/m2 for patients ≥18 years old. (For children BMI was not calculated because accurate information on age in months required to calculate BMI z-scores was not provided for privacy reasons.)
BMI, body mass index; SUEA, severe, uncontrolled eosinophilic asthma.