Table 1

Subject demographics, PFT metrics and imaging-derived parameters

Subject demographics
Pulmonary function tests
 FVC (L)4.1±0.92.6±0.8
 FVC % predicted94±1565±19
 DLCO (mL/min/mm Hg)26±6.011±3.2
 DLCO % predicted93±1748±14
Xenon transfer metrics
 VentilationMean 0.51±0.060.45±0.06
 % ReferenceMean 99±1188±11
 BarrierMean (×10−2)0.52±0.130.91±0.17
 % ReferenceMean 106±26188±36
 BarrierHigh %3.0±8.048.7±32.2
 RBCMean (×10−2)0.28±0.060.19±0.06
 % ReferenceMean 108±2372±25
 RBCLow %14.6±6.941.9±21.2
 RBC/barrierMean 0.58±0.130.21±0.07
 % ReferenceMean 108±2440±12
CT metrics
 CT fibrosis score %N/A17.4±12.2
  • Values listed are in the format mean±SD. The %ReferenceMean values are compared relative to reference values derived from a cohort of healthy volunteers.

  • DLCO, diffusing capacity of the lungs for carbon monoxide; FVC, forced vital capacity; IPF, idiopathic pulmonary fibrosis; RBC, red blood cell.