Subject demographics, PFT metrics and imaging-derived parameters
| Healthy | IPF | |
| Subject demographics | ||
| Number | 13 | 12 |
| Male/female | 9/4 | 10/2 |
| Age | 33.6±15.7 | 66.0±6.4 |
| Pulmonary function tests | ||
| FVC (L) | 4.1±0.9 | 2.6±0.8 |
| FVC % predicted | 94±15 | 65±19 |
| DLCO (mL/min/mm Hg) | 26±6.0 | 11±3.2 |
| DLCO % predicted | 93±17 | 48±14 |
| Xenon transfer metrics | ||
| VentilationMean | 0.51±0.06 | 0.45±0.06 |
| % ReferenceMean | 99±11 | 88±11 |
| BarrierMean (×10−2) | 0.52±0.13 | 0.91±0.17 |
| % ReferenceMean | 106±26 | 188±36 |
| BarrierHigh % | 3.0±8.0 | 48.7±32.2 |
| RBCMean (×10−2) | 0.28±0.06 | 0.19±0.06 |
| % ReferenceMean | 108±23 | 72±25 |
| RBCLow % | 14.6±6.9 | 41.9±21.2 |
| RBC/barrierMean | 0.58±0.13 | 0.21±0.07 |
| % ReferenceMean | 108±24 | 40±12 |
| CT metrics | ||
| CT fibrosis score % | N/A | 17.4±12.2 |
Values listed are in the format mean±SD. The %ReferenceMean values are compared relative to reference values derived from a cohort of healthy volunteers.
DLCO, diffusing capacity of the lungs for carbon monoxide; FVC, forced vital capacity; IPF, idiopathic pulmonary fibrosis; RBC, red blood cell.