| Study Data n=11 | Baseline Pre-modafinil | Day 10 modafinil 200 mg/day | Day 40 Modafinil 200 mg/day | Improvement At 40 days | 4 week NIV2 | Improvement After 4 weeks Of NIV | 1 year study of NIV 3 | Improvement At 1 year | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Mean Arterial Pa02 kPa On air (range) | 5.8 (4.3–7.3) | 6.7 (4.1–8.1) | 7.67 (5.5–9.3) | +1.87 kPa | 7.5 | +1.7 | 7.0 | +2.4 | ||
| Mean Arterial PaC02 kPa On air(range) | 8.6 (6.5–13.4) | 6.7 (5.2–8.0) | 5.9 (5.0–6.3) | −2.7 kPa | 7.5 | −0.7 | 7.2 | −1.35 | ||
| Mean daytime saturations on air (range) | 75% (58–89) | 85% (65–92) | 90% (79–95) | 15% | No data | No data | No data | No data | ||
| Mean overnight saturations on air(range) | 72% (58–86) | 79% (67–89) | 83% (68–91) | +11% | 79% | 0% | No data | No data | ||
| Mean FEV-1 (%) | 28% | 30% | 32% | +4% | 31% | +6% | 25% | −1% | ||
| Mean FVC (%) | 48% | 45% | 53% | +5% | No data | No data | 54% | No data | ||